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来自艾滋病病毒包膜免疫人群的T淋巴细胞所识别的抗原肽。

Antigenic peptides recognized by T lymphocytes from AIDS viral envelope-immune humans.

作者信息

Berzofsky J A, Bensussan A, Cease K B, Bourge J F, Cheynier R, Lurhuma Z, Salaün J J, Gallo R C, Shearer G M, Zagury D

机构信息

Metabolism Branch, National Cancer Institute, Bethesda, Maryland 20892.

出版信息

Nature. 1988 Aug 25;334(6184):706-8. doi: 10.1038/334706a0.

Abstract

T-lymphocyte immunity is likely to be an important component of the immune defence against the AIDS virus, because helper T cells are necessary for the antibody response as well as the cytotoxic response. We have previously predicted two antigenic sites of the viral envelope protein gp120 likely to be recognized by T lymphocytes, based on their ability to fold as amphipathic helices, and have demonstrated that these are recognized by T cells of mice immunized with gp120 (ref. 1). A peptide corresponding to one of these sites can also be induce immunity in mice to the whole gp120 protein. Because many clinically healthy seropositive blood donors have already lost their T-cell proliferative response to specific antigen, we tested the response to these synthetic peptides of lymphocytes from 14 healthy human volunteers who had been immunized with a recombinant vaccinia virus containing the AIDS viral envelope gene and boosted with a recombinant fragment. Eight of the 14 responded to one peptide, and four to the other peptide, not included in the boost. These antigenic sites recognized by human T cells may be useful components of a vaccine against AIDS. We also found a correlation between boosting with antigen-antibody complexes (compared to free antigen) and higher stimulation indices, suggesting a more effective method of immunization.

摘要

T淋巴细胞免疫很可能是抵抗艾滋病病毒免疫防御的一个重要组成部分,因为辅助性T细胞对于抗体反应和细胞毒性反应都是必需的。我们之前基于病毒包膜蛋白gp120折叠成两亲性螺旋的能力,预测了两个可能被T淋巴细胞识别的抗原位点,并已证明这些位点能被用gp120免疫的小鼠的T细胞所识别(参考文献1)。对应于其中一个位点的肽段也能在小鼠中诱导对整个gp120蛋白的免疫。由于许多临床健康的血清阳性献血者已经失去了对特定抗原的T细胞增殖反应,我们检测了14名健康人类志愿者淋巴细胞对这些合成肽段的反应,这些志愿者曾用含有艾滋病病毒包膜基因的重组痘苗病毒免疫,并以重组片段加强免疫。14名志愿者中有8名对一种肽段有反应,4名对加强免疫中未包含的另一种肽段有反应。这些被人类T细胞识别的抗原位点可能是艾滋病疫苗的有用组成部分。我们还发现用抗原-抗体复合物加强免疫(与游离抗原相比)和更高的刺激指数之间存在相关性,这表明了一种更有效的免疫方法。

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