Division of Pulmonary Medicine, Ishikawa-ken Saiseikai Kanazawa Hospital, Kanazawa 920-0353, Japan.
Expert Rev Clin Immunol. 2014 May;10(5):647-56. doi: 10.1586/1744666X.2014.892829. Epub 2014 Mar 3.
With regard to fungal colonization and fungal sensitization, the goals of fungus-associated asthma management are as follows: 1) to survey fungi colonizing the airways of patients repeatedly; 2) to evaluate the tendency of the colonizing fungi to sensitize patients and the influence on clinical manifestations of asthma; 3) to follow disease development to allergic bronchopulmonary mycosis or sinobronchial allergic mycosis; and 4) to determine whether fungal eradication from the airway of patients is beneficial from the viewpoints of future risk factors. Recent developments in molecular biological analyses have facilitated the identification of basidiomycetous fungi that were not previously thought to be of concern in fungal allergy. The total control of fungus-associated asthma will be accomplished by environmental management established from the viewpoint of both the ecology and life cycle of the responsible fungi.
关于真菌定植和真菌致敏，真菌相关性哮喘管理的目标如下：1）反复调查气道定植真菌；2）评估定植真菌致敏患者的倾向以及对哮喘临床表现的影响；3）随访疾病发展至变应性支气管肺曲霉病或鼻支气管变应性真菌病；4）从未来危险因素的角度确定患者气道内真菌清除是否有益。分子生物学分析的最新进展促进了担子菌真菌的鉴定，这些真菌以前被认为与真菌过敏无关。通过从责任真菌的生态学和生命周期的角度建立环境管理，将实现真菌相关性哮喘的全面控制。
