Agarwal Ritesh, Sehgal Inderpaul S, Dhooria Sahajal, Aggarwal Ashutosh N
Professor Department of Pulmonary Medicine Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
Assistant Professor.
Med Mycol. 2019 Apr 1;57(Supplement_2):S110-S117. doi: 10.1093/mmy/myy063.
Fungal asthma broadly encompasses the presence of fungal sensitization or fungal allergy in patients with asthma. The clinical presentation of fungal asthma can vary from fungal-sensitized asthma at one end to allergic bronchopulmonary mycosis at the other end of the spectrum. Here we present five cases that illustrate some of the most challenging aspects of the diagnosis and management of fungal asthma. The cases are aimed at elucidating complex clinical presentations in fungal asthma such as allergic bronchopulmonary mycosis presenting with normal immunoglobulin E (IgE) values, the role of several different fungi in causing allergic mycosis, newer treatments like omalizumab (and mepolizumab), and a complication of long-standing allergic bronchopulmonary aspergillosis, namely, chronic pulmonary aspergillosis.
真菌性哮喘广义上包括哮喘患者中存在真菌致敏或真菌过敏的情况。真菌性哮喘的临床表现范围广泛，一端是真菌致敏性哮喘，另一端是变应性支气管肺曲霉菌病。在此，我们呈现5例病例，以说明真菌性哮喘诊断和管理中一些最具挑战性的方面。这些病例旨在阐明真菌性哮喘中复杂的临床表现，如免疫球蛋白E（IgE）值正常的变应性支气管肺曲霉菌病、几种不同真菌在引起变应性真菌病中的作用、奥马珠单抗（和美泊利单抗）等新型治疗方法，以及长期变应性支气管肺曲霉菌病的一种并发症，即慢性肺曲霉菌病。
