Miadonna A, Tedeschi A, Leggieri E, Lorini M, Qualizza R, Froldi M, Zanussi C
Department of Internal Medicine, University of Milan, Ospedale Policlinico, Italy.
Ann Allergy. 1988 Sep;61(3):220-3.
Nasal challenge and intradermal injection with substance P (SP) were performed in five normal subjects and in five patients suffering from allergic rhinitis. No clinical symptoms, local histamine release, or modifications of nasal airway resistance were observed when SP was insufflated in the nose. Conversely, intradermal injection with SP caused a wheal and flare reaction in all the studied subjects. The different response to SP is likely to be due to the heterogeneity of human skin and nasal mucosa mast cells as far as sensitivity to histamine-releasing agents is concerned. Our findings indicate that SP has no relevant effect on human nasal mucosa, even if a synergetic action of SP with other allergic mediators cannot be excluded. The role of SP in the pathogenesis of allergic diseases in humans remains to be defined and deserves further study.
对5名正常受试者和5名患有过敏性鼻炎的患者进行了鼻激发试验和皮内注射P物质（SP）。当将SP吹入鼻腔时，未观察到临床症状、局部组胺释放或鼻气道阻力的改变。相反，皮内注射SP在所有研究对象中均引起了风团和潮红反应。就对组胺释放剂的敏感性而言，对SP的不同反应可能是由于人类皮肤和鼻黏膜肥大细胞的异质性所致。我们的研究结果表明，即使不能排除SP与其他过敏介质的协同作用，SP对人类鼻黏膜也没有相关影响。SP在人类过敏性疾病发病机制中的作用仍有待确定，值得进一步研究。
