尼莫地平对小鼠酒精代谢的影响。

Nimodipine's effect on alcohol disposition in mice.

作者信息

Gilliam D M, Isaacson R L, Burright R G, Johnston J E, Fahey J M, Vargas D

机构信息

Department of Psychology, State University of New York, Albany 12222.

出版信息

Alcohol. 1988 May-Jun;5(3):259-61. doi: 10.1016/0741-8329(88)90061-4.

DOI:10.1016/0741-8329(88)90061-4

PMID:2458112

Abstract

Adult Binghamton Heterogeneous male mice received either nimodipine (5 mg/kg in saline) or vehicle 10 minutes prior to ethanol (1.02 g/kg) administration. Blood samples were obtained at 2, 10, 30, 60 and 120 minutes following the alcohol injection for determination of ethanol content. Although mean blood alcohol concentrations (BACs) were similar for both groups, nimodipine increased the variance in blood alcohol levels. Therefore, while nimodipine may alter alcohol pharmacokinetics through its interaction(s) with the genetic characteristics of the individual animal, the ability of this calcium slow channel blocking agent to enhance the psychotropic effects of alcohol cannot be due to altered absorption or elimination of the intoxicant.

摘要

成年宾厄姆顿杂种雄性小鼠在给予乙醇（1.02 g/kg）前10分钟，接受尼莫地平（5 mg/kg溶于生理盐水）或赋形剂注射。在酒精注射后的2、10、30、60和120分钟采集血样，以测定乙醇含量。尽管两组的平均血醇浓度（BAC）相似，但尼莫地平增加了血醇水平的方差。因此，虽然尼莫地平可能通过与个体动物的遗传特征相互作用来改变酒精的药代动力学，但这种钙慢通道阻滞剂增强酒精精神效应的能力并非由于改变了毒物的吸收或消除。