Cooke I R, Gelperin A
Department of Biology, Princeton University, New Jersey.
Cell Tissue Res. 1988 Jul;253(1):77-81. doi: 10.1007/BF00221742.
Immunohistochemical techniques were used to study the distribution of gamma-amino butyric acid (GABA)-like immunoreactive neurons in the nervous system of the slug Limax maximus. Approximately 170 GABA-like immunoreactive cell bodies were found in the central nervous system. These were located in the cerebral, buccal and pedal ganglia. Most GABA-like immunoreactive neurons had small cell bodies, which were aggregated into discrete clusters within the cerebral and pedal ganglia. Three pairs of longer, uniquely identifiable, GABA-like immunoreactive cells were found in the cerebral ganglion. GABA-like immunoreactive nerve fibres were also found in all of the central ganglia but were absent from peripheral nerves. These results suggest that GABA acts as a central neurotransmitter in the slug. The possible roles of GABA-ergic neurotransmission in the slug are discussed.
采用免疫组织化学技术研究了大蛞蝓神经系统中γ-氨基丁酸（GABA）样免疫反应性神经元的分布。在中枢神经系统中发现了约170个GABA样免疫反应性细胞体。它们位于脑、口和足神经节中。大多数GABA样免疫反应性神经元具有小的细胞体，这些细胞体在脑和足神经节内聚集成离散的簇。在脑神经元中发现了三对较长的、可唯一识别的GABA样免疫反应性细胞。在所有中枢神经节中也发现了GABA样免疫反应性神经纤维，但外周神经中没有。这些结果表明，GABA在大蛞蝓中作为一种中枢神经递质发挥作用。讨论了GABA能神经传递在大蛞蝓中的可能作用。
