真兽类 Mas 相关 G 蛋白偶联受体基因的比较基因组分析。
Comparative genomic analysis of eutherian Mas-related G protein-coupled receptor genes.
机构信息
Laboratory of Genomics, Centre of Animal Reproduction, Zagreb, Croatia.
出版信息
Gene. 2014 Apr 25;540(1):16-9. doi: 10.1016/j.gene.2014.02.049. Epub 2014 Feb 26.
The present study made attempts to update comprehensive eutherian Mas-related G protein-coupled receptor gene data sets, using public eutherian genomic sequence data sets and new genomics and molecular evolution tests. Among 254 potential coding sequences, the most comprehensive gene data set of eutherian Mas-related G protein-coupled receptor genes included 119 complete coding sequences that described eight major gene clusters. The present analysis integrated gene annotations, phylogenetic analysis and protein molecular evolution analysis and first explained differential gene expansion patterns of eutherian Mas-related G protein-coupled receptor genes. The updated classification and nomenclature of eutherian Mas-related G protein-coupled receptor genes were proposed as new framework of future experiments.
本研究试图利用公共真兽类基因组序列数据集和新的基因组学和分子进化测试来更新综合的 Mas 相关 G 蛋白偶联受体基因数据集。在 254 个潜在的编码序列中，最全面的真兽类 Mas 相关 G 蛋白偶联受体基因数据集包括 119 个完整的编码序列，描述了 8 个主要的基因簇。本分析综合了基因注释、系统发育分析和蛋白质分子进化分析，并首次解释了真兽类 Mas 相关 G 蛋白偶联受体基因的差异基因扩展模式。提出了更新的真兽类 Mas 相关 G 蛋白偶联受体基因的分类和命名法，作为未来实验的新框架。
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