Laboratory of Genomics, Centre of Animal Reproduction, Zagreb, Croatia.
Funct Integr Genomics. 2012 Nov;12(4):599-607. doi: 10.1007/s10142-012-0291-2. Epub 2012 Aug 15.
The interferon-γ-inducible GTPases, IFGGs, are intracellular proteins involved in immune response against pathogens. A comprehensive comparative genomic review and analysis of eutherian IFGGs was carried out using public genomic sequences. The 64 eutherian IFGG genes were examined in detail and annotated. The eutherian IFGG promoter types were first catalogued followed by a phylogenetic analysis of eutherian IFGGs, which described five major IFGG clusters. The patterns of differential gene expansions and protein regions that may regulate IFGG catalytic features suggested a new classification of eutherian IFGGs. This mini-review has also provided new tests of reliability of public genomic sequences as well as tests of protein molecular evolution.
γ-干扰素诱导的 GTPases（IFGGs）是参与针对病原体的免疫反应的细胞内蛋白。使用公共基因组序列对真兽类 IFGGs 进行了全面的比较基因组综述和分析。详细检查和注释了 64 个真兽类 IFGG 基因。首先对真兽类 IFGG 启动子类型进行了编目，然后对真兽类 IFGG 进行了系统发育分析，描述了五个主要的 IFGG 簇。基因扩展和可能调节 IFGG 催化特征的蛋白质区域的差异模式表明了真兽类 IFGG 的新分类。这篇小型综述还提供了对公共基因组序列可靠性的新测试以及对蛋白质分子进化的测试。
