Mulder E, Frings-Meuthen P, von der Wiesche M, Clément G, Linnarsson D, Paloski W H, Wuyts F L, Zange J, Rittweger J
Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany.
J Musculoskelet Neuronal Interact. 2014 Mar;14(1):111-23.
This work provides a reference for future papers originating from this study by providing basic results on body mass, urine volume, and hemodynamic changes to 5 days of bed rest (BR) and by describing acute cardio-respiratory/mechanographic responses to a short versatile upright exercise battery.
Ten male subjects (mean ± SEM age: 29.4 ± 1.5 years; height: 178.8 ± 1.5 cm; body mass: 77.7 ± 1.5 kg) performed, in random order, 5 days of 6° head-down tilt (HDT) BR with no exercise (CON), or BR with daily 25 minutes of quiet upright standing (STA) or upright locomotion replacement training (LRT).
Plasma volume, exercise capacity and orthostatic tolerance decreased similarly between interventions following 5 days of BR. Upright heart rate during LRT and STA increased throughout BR; from 137 ± 4 bpm to 146 ± 4 bpm for LRT (P<0.01); and from 90 ± 3 bpm to 102 ± 6 bpm (P<0.001) for STA.
the overall similarity in the response to BR, and increase in upright heart rate during the LRT sessions suggest early and advancing cardiovascular deconditioning during 5 days of BR bed rest, which was not prevented by the versatile exercise regime.
本研究通过提供卧床休息（BR）5天期间体重、尿量和血流动力学变化的基础结果，并描述对短期通用直立运动组的急性心肺/力学反应，为源自本研究的未来论文提供参考。
10名男性受试者（平均±标准误年龄：29.4±1.5岁；身高：178.8±1.5厘米；体重：77.7±1.5千克）以随机顺序进行5天的6°头低位倾斜（HDT）BR，其中一组不进行运动（CON），或一组进行每天25分钟的安静直立站立（STA）或直立运动替代训练（LRT）。
BR 5天后，各干预组之间血浆容量、运动能力和直立耐受性的下降情况相似。LRT和STA期间的直立心率在整个BR过程中均增加；LRT组从137±4次/分钟增加到146±4次/分钟（P<0.01）；STA组从90±3次/分钟增加到102±6次/分钟（P<0.001）。
对BR反应的总体相似性，以及LRT期间直立心率的增加表明，在BR卧床休息5天期间早期和进展性心血管失适应，而通用运动方案未能预防这种情况。
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