关节代谢生物标志物、手部骨关节炎与手部疼痛及功能之间的关联：约翰斯顿县骨关节炎项目

Associations between biomarkers of joint metabolism, hand osteoarthritis, and hand pain and function: the Johnston County Osteoarthritis Project.

作者信息

Aslam Imran, Perjar Irina, Shi Xiaoyan A, Renner Jordan B, Kraus Virginia B, Golightly Yvonne M, Jordan Joanne M, Nelson Amanda E

机构信息

From the Northeast Ohio Medical School, Rootstown, Ohio; the School of Medicine, the Thurston Arthritis Research Center, the Department of Radiology, the Department of Epidemiology, and the Department of Orthopedics, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill; SAS Institute, Cary; Duke University School of Medicine, Durham, NC, USA.

出版信息

J Rheumatol. 2014 May;41(5):938-44. doi: 10.3899/jrheum.130904. Epub 2014 Mar 1.

DOI:10.3899/jrheum.130904

PMID:24584914

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4008682/

Abstract

OBJECTIVE

To determine the associations between joint metabolism biomarkers and hand radiographic osteoarthritis [(rOA), based on Kellgren Lawrence (KL) grade ≥ 2], symptoms, and function.

METHODS

Cross-sectional data were available for 663 participants (mean age 63 yrs, 63% white, 49% women). Three definitions of hand rOA were considered: (1) a composite measure involving at least 3 hand joints distributed bilaterally with 2 of 3 in the same joint group, including ≥ 1 distal interphalangeal joint, without metacarpophalangeal (MCP) swelling; (2) rOA in at least 1 joint of a group; and (3) number of joints with KL ≥ 2. We assessed hand symptoms and the 15-item Australian Canadian Hand Osteoarthritis Index (AUSCAN; Likert format). We measured serum cartilage oligomeric matrix protein (sCOMP), hyaluronic acid (sHA), carboxy-terminal propeptide of type II collagen, type II collagen degradation product, urinary C-terminal crosslinked telopeptide of type II collagen, and urinary N-terminal crosslinked telopeptide. Linear regression models were performed to assess associations between each biomarker with hand rOA, AUSCAN, and symptoms, adjusting for age, sex, race, current smoking/drinking status, body mass index, and hip and knee rOA.

RESULTS

In adjusted analyses, MCP (p < 0.0001) and carpometacarpal rOA (p = 0.003), and a higher number of hand joints with rOA (p = 0.009), were associated with higher levels of sHA. Positive associations were seen between AUSCAN and hand symptoms and levels of sCOMP (p ≤ 0.003) and sHA (p ≤ 0.048).

CONCLUSION

Hand symptoms and higher AUSCAN scores were independently associated with higher levels of both sCOMP and sHA; hand rOA was associated only with sHA levels.

摘要

目的

确定关节代谢生物标志物与手部放射学骨关节炎（基于凯尔格伦-劳伦斯（KL）分级≥2级的rOA）、症状及功能之间的关联。

方法

有663名参与者（平均年龄63岁，63%为白人，49%为女性）的横断面数据。考虑了手部rOA的三种定义：（1）一种综合测量方法，涉及至少3个双侧分布的手部关节，其中3个中有2个在同一关节组，包括≥1个远端指间关节，无掌指（MCP）肿胀；（2）一组中至少1个关节的rOA；（3）KL≥2的关节数量。我们评估了手部症状和15项澳大利亚-加拿大手部骨关节炎指数（AUSCAN；李克特量表形式）。我们测量了血清软骨寡聚基质蛋白（sCOMP）、透明质酸（sHA）、II型胶原羧基末端前肽、II型胶原降解产物、尿II型胶原C末端交联端肽和尿II型胶原N末端交联端肽。进行线性回归模型以评估每种生物标志物与手部rOA、AUSCAN和症状之间的关联，并对年龄、性别、种族、当前吸烟/饮酒状况、体重指数以及髋部和膝部rOA进行校正。