Inhibition of folate-dependent enzymes by 7-OH-methotrexate.

Suppr

超能文献

作者信息

Sholar P W, Baram J, Seither R, Allegra C J

机构信息

Division of Cancer Treatment, National Cancer Institute, Bethesda, MD 20892.

出版信息

Biochem Pharmacol. 1988 Sep 15;37(18):3531-4. doi: 10.1016/0006-2952(88)90709-5.

DOI:10.1016/0006-2952(88)90709-5

PMID:2458733

Abstract

摘要

相似文献

Inhibition of folate-dependent enzymes by 7-OH-methotrexate.

Biochem Pharmacol. 1988 Sep 15;37(18):3531-4. doi: 10.1016/0006-2952(88)90709-5.

LY231514, a pyrrolo[2,3-d]pyrimidine-based antifolate that inhibits multiple folate-requiring enzymes.LY231514，一种基于吡咯并[2,3-d]嘧啶的抗叶酸剂，可抑制多种需要叶酸的酶。

Cancer Res. 1997 Mar 15;57(6):1116-23.

Inhibition of 5-aminoimidazole-4-carboxamide ribotide transformylase, adenosine deaminase and 5'-adenylate deaminase by polyglutamates of methotrexate and oxidized folates and by 5-aminoimidazole-4-carboxamide riboside and ribotide.甲氨蝶呤和氧化叶酸的聚谷氨酸酯以及5-氨基咪唑-4-甲酰胺核苷和核苷酸对5-氨基咪唑-4-甲酰胺核糖核苷酸转甲酰酶、腺苷脱氨酶和5'-腺苷酸脱氨酶的抑制作用

Biochem J. 1986 May 15;236(1):193-200. doi: 10.1042/bj2360193.

Inhibitors of thymidylate synthase and glycinamide ribonucleotide transformylase.胸苷酸合成酶和甘氨酰胺核糖核苷酸转甲酰基酶抑制剂。

Adv Exp Med Biol. 1994;370:179-83. doi: 10.1007/978-1-4615-2584-4_39.

Biochemical and biological studies on 2-desamino-2-methylaminopterin, an antifolate the polyglutamates of which are more potent than the monoglutamate against three key enzymes of folate metabolism.对2-脱氨基-2-甲基氨基蝶呤的生化与生物学研究，该抗叶酸剂的多聚谷氨酸盐对叶酸代谢的三种关键酶的活性比单谷氨酸盐更强。

Cancer Res. 1992 Apr 15;52(8):2148-55.

Antifolates in rheumatoid arthritis: a hypothetical mechanism of action.类风湿关节炎中的抗叶酸剂：一种假设的作用机制。

Clin Exp Rheumatol. 1993 Mar-Apr;11 Suppl 8:S101-5.

Newer antifolates in cancer therapy.

Prog Drug Res. 1995;44:129-57. doi: 10.1007/978-3-0348-7161-7_4.

Differences in methotrexate and 7-hydroxymethotrexate inhibition of folate-dependent enzymes of purine nucleotide biosynthesis.甲氨蝶呤和7-羟基甲氨蝶呤对嘌呤核苷酸生物合成中叶酸依赖性酶的抑制作用差异。

Biochem J. 1994 Jun 15;300 ( Pt 3)(Pt 3):627-9. doi: 10.1042/bj3000627.

Polyglutamation of methotrexate with common polymorphisms in reduced folate carrier, aminoimidazole carboxamide ribonucleotide transformylase, and thymidylate synthase are associated with methotrexate effects in rheumatoid arthritis.甲氨蝶呤的多聚谷氨酸化与还原型叶酸载体、氨基咪唑甲酰胺核糖核苷酸转甲酰基酶和胸苷酸合成酶中的常见多态性与类风湿关节炎中甲氨蝶呤的疗效相关。

Arthritis Rheum. 2004 Sep;50(9):2766-74. doi: 10.1002/art.20460.

Novel pyrrolo[2,3-d]pyrimidine antifolate TNP-351: cytotoxic effect on methotrexate-resistant CCRF-CEM cells and inhibition of transformylases of de novo purine biosynthesis.新型吡咯并[2,3-d]嘧啶抗叶酸剂TNP-351：对甲氨蝶呤耐药的CCRF-CEM细胞的细胞毒性作用及对嘌呤从头合成的转甲酰酶的抑制作用

Cancer Chemother Pharmacol. 1994;34(4):273-9. doi: 10.1007/BF00686032.

引用本文的文献

Prevention and Treatment of Acute Kidney Injury Associated with High-Dose Methotrexate.大剂量甲氨蝶呤相关急性肾损伤的防治

Kidney360. 2025 Mar 1;6(3):476-481. doi: 10.34067/KID.0000000725. Epub 2025 Jan 31.

Pharmacology and Optimization of Thiopurines and Methotrexate in Inflammatory Bowel Disease.炎症性肠病中硫嘌呤和甲氨蝶呤的药理学及优化

Clin Pharmacokinet. 2016 Mar;55(3):257-74. doi: 10.1007/s40262-015-0316-9.

Review article: The pharmacokinetics and pharmacodynamics of drugs used in inflammatory bowel disease treatment.综述文章：用于治疗炎症性肠病的药物的药代动力学和药效学

Eur J Clin Pharmacol. 2015 Jul;71(7):773-99. doi: 10.1007/s00228-015-1862-7. Epub 2015 May 27.

From methotrexate to pemetrexed and beyond. A review of the pharmacodynamic and clinical properties of antifolates.从甲氨蝶呤到培美曲塞及其他。抗叶酸药物的药效学和临床特性综述。

Invest New Drugs. 2006 Jan;24(1):37-77. doi: 10.1007/s10637-005-4541-1.

Folate, antifolates, and folate analogs in pediatric oncology.儿科肿瘤学中的叶酸、抗叶酸剂和叶酸类似物。

Invest New Drugs. 1996;14(1):101-11. doi: 10.1007/BF00173686.

Inhibition of 7-hydroxymethotrexate formation by amsacrine.安吖啶对7-羟基甲氨蝶呤形成的抑制作用。

Cancer Chemother Pharmacol. 1991;28(5):377-83. doi: 10.1007/BF00685693.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验