Munshi T A, Volochniouk D, Hassan T, Mazhar N
Queen's University, 385 Princess Street, Kingston, ON, Canada K7L 1B9.
Case Rep Psychiatry. 2014;2014:513108. doi: 10.1155/2014/513108. Epub 2014 Jan 23.
Clozapine is an atypical antipsychotic used for treatment resistant schizophrenia. Its potential to induce agranulocytosis is well known but it can also cause myocarditis. Clozapine is the only antipsychotic known to induce this side effect, typically early in the treatment, and literature is scarce on this condition. We are presenting a case report of a 21-year-old schizophrenic male who developed myocarditis within 3 weeks of starting on clozapine for his treatment resistant psychosis. We then aim to review some of the available literature and raise awareness among physicians as this condition can potentially be fatal if not detected early.
氯氮平是一种用于治疗难治性精神分裂症的非典型抗精神病药物。其诱发粒细胞缺乏症的可能性众所周知，但它也可导致心肌炎。氯氮平是已知唯一能诱发这种副作用的抗精神病药物，通常在治疗早期出现，而关于这种情况的文献很少。我们报告一例21岁男性精神分裂症患者，在开始使用氯氮平治疗难治性精神病后3周内发生心肌炎。然后，我们旨在回顾一些现有文献，并提高医生的认识，因为如果不及早发现，这种情况可能会致命。
