Kan Saori, Konishi Eiichi, Arita Takahiro, Ikemoto Chika, Takenaka Hideya, Yanagisawa Akio, Katoh Norito, Asai Jun
Department of Dermatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
J Cutan Pathol. 2014 Jul;41(7):561-7. doi: 10.1111/cup.12322. Epub 2014 Apr 9.
Recent studies have showed podoplanin expression in several tumors, which has been associated with lymph node metastasis and poor prognosis. Podoplanin expression in cancer-associated fibroblasts also correlates with tumor progression. However, the association of podoplanin expression with melanomas remains unclear.
To clarify the prognostic significance of podoplanin in melanoma, podoplanin expression in tumor cells and cancer-associated fibroblasts was examined by immunohistochemistry in tissue samples collected from 55 melanoma patients.
Podoplanin expression in tumor cells was identified in 38 patients (69.1%) but did not show correlation with characteristics of tumor progression such as tumor thickness (p = 0.52) and sentinel lymph node (SLN) metastasis (p = 0.79). Podoplanin expression in cancer-associated fibroblasts was observed in 25 patients (45.5%), 11 of whom (44.0%) had SLN metastasis. In contrast, only 4 of 30 patients (13.3%) with podoplanin-negative cancer-associated fibroblasts exhibited SLN metastasis. Podoplanin-positive cancer-associated fibroblasts were associated with increased tumor thickness and SLN metastasis. Furthermore, patients with podoplanin-positive cancer-associated fibroblasts had poorer survival than those with podoplanin-negative cancer-associated fibroblasts (p = 0.0148).
The presence of podoplanin expression in cancer-associated fibroblasts correlates with aggressive behavior in melanoma and might therefore serve as a useful prognostic factor for patients with melanoma.
最近的研究表明，血小板反应蛋白-1在多种肿瘤中表达，这与淋巴结转移和预后不良有关。癌相关成纤维细胞中血小板反应蛋白-1的表达也与肿瘤进展相关。然而，血小板反应蛋白-1表达与黑色素瘤之间的关系仍不清楚。
为了阐明血小板反应蛋白-1在黑色素瘤中的预后意义，通过免疫组织化学检测了55例黑色素瘤患者组织样本中肿瘤细胞和癌相关成纤维细胞中血小板反应蛋白-1的表达。
38例患者（69.1%）肿瘤细胞中检测到血小板反应蛋白-1表达，但与肿瘤厚度（p = 0.52）和前哨淋巴结（SLN）转移（p = 0.79）等肿瘤进展特征无相关性。25例患者（45.5%）癌相关成纤维细胞中观察到血小板反应蛋白-1表达，其中11例（44.0%）发生SLN转移。相比之下，30例血小板反应蛋白-1阴性癌相关成纤维细胞患者中只有4例（占13.3%）发生SLN转移。血小板反应蛋白-1阳性癌相关成纤维细胞与肿瘤厚度增加和SLN转移相关。此外，血小板反应蛋白-1阳性癌相关成纤维细胞患者的生存率低于血小板反应蛋白-1阴性癌相关成纤维细胞患者（p = 0.0148）。
癌相关成纤维细胞中血小板反应蛋白-1的表达与黑色素瘤的侵袭性行为相关，因此可能作为黑色素瘤患者有用的预后因素。
