Laboratory of Veterinary Surgery, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan.
Veterinary Medical Center, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan.
J Vet Med Sci. 2021 Nov 24;83(11):1795-1799. doi: 10.1292/jvms.20-0608. Epub 2021 Oct 18.
Podoplanin is expressed in various human tumors where it promotes tumor progression, epithelial-mesenchymal transition, and distant metastasis. Podoplanin is also expressed in cancer-associated fibroblasts and induces tumor malignancy. The objective of this study was to evaluate podoplanin expression in various types of feline tumor tissues. Immunohistochemical analysis revealed that podoplanin was expressed in cells of 13/15 (87%) squamous cell carcinomas and 5/19 (26%) fibrosarcomas. Moreover, cancer-associated fibroblasts expressed podoplanin in most tumor types, including 18/21 (86%) mammary adenocarcinoma tissues. Our findings demonstrate that various types of feline tumor tissues expressed podoplanin, indicating the importance of the comparative aspects of podoplanin expression, which may be used as a novel research model for podoplanin biology.
波形蛋白在各种人类肿瘤中表达，促进肿瘤进展、上皮-间充质转化和远处转移。波形蛋白也在癌相关成纤维细胞中表达，并诱导肿瘤恶性转化。本研究旨在评估波形蛋白在各种类型猫肿瘤组织中的表达。免疫组织化学分析显示，波形蛋白在 13/15（87%）例鳞状细胞癌和 5/19（26%）纤维肉瘤的细胞中表达。此外，癌相关成纤维细胞在包括 18/21（86%）例乳腺腺癌组织在内的大多数肿瘤类型中表达波形蛋白。我们的研究结果表明，各种类型的猫肿瘤组织表达波形蛋白，表明波形蛋白表达的比较方面的重要性，可作为波形蛋白生物学的新的研究模型。
