Bonakdaran Shokoufeh, Kharaqani Banafsheh
Endocrine Research Center, Ghaem Hospital, Ahmadabad Street, Mashhad, Iran.
Curr Diabetes Rev. 2014 Mar;10(2):113-7. doi: 10.2174/1573399810666140228160938.
The relationship between elevated serum uric acid level and metabolic syndrome (MS) has been debated. There is no data concerning this relation in Iranian population-based studies. The aim of this study was to determine the prevalence of hyperuricamia and its association with MS in type 2 diabetes mellitus (DM).
This was a cross- sectional study in 1978 diabetic patients. Hyperuricamia was defined as uric acid ≥ 7 and ≥ 5.5 mg/dl for men and women respectively. Diagnosis of metabolic syndrome was based on ATPIII criteria. Clinical and biochemical parameters in hyperuricaemic and normouricaemic patients compared with other.
The prevalence of hyperuricaemia and metabolic syndrome was 12.7% and 65.5% respectively. The prevalence of MS significantly increased in the highest quartile of uric acid levels compared with lowest quartile (74.4% vs 55.9%, p<0.001). Serum uric acid had positive association with cholesterol, triglyceride, non-HDL cholesterol and a negative association with fasting blood sugar (FBS), glycosylated hemoglobin (HbA1C) and HDL cholesterol. Possible independent biochemical predictors of hyperuricamia were cholesterol, triglyceride, creatnine and FBS.
The prevalence of MS and its components increases with increasing levels of uric acid in type 2 diabetes. Regular assessment of uric acid could give information for predicting of MS and prevention of atherosclerosis in type 2 diabetes.
血清尿酸水平升高与代谢综合征（MS）之间的关系一直存在争议。在伊朗基于人群的研究中，尚无关于这种关系的数据。本研究的目的是确定2型糖尿病（DM）患者中高尿酸血症的患病率及其与MS的关联。
这是一项对1978例糖尿病患者的横断面研究。高尿酸血症的定义为男性尿酸≥7mg/dl，女性尿酸≥5.5mg/dl。代谢综合征的诊断基于ATPIII标准。将高尿酸血症患者和正常尿酸血症患者的临床和生化参数进行比较。
高尿酸血症和代谢综合征的患病率分别为12.7%和65.5%。与最低四分位数相比，尿酸水平最高四分位数的MS患病率显著增加（74.4%对55.9%，p<0.001）。血清尿酸与胆固醇、甘油三酯、非高密度脂蛋白胆固醇呈正相关，与空腹血糖（FBS）、糖化血红蛋白（HbA1C）和高密度脂蛋白胆固醇呈负相关。高尿酸血症可能的独立生化预测因素为胆固醇、甘油三酯、肌酐和FBS。
2型糖尿病患者中，MS及其组分的患病率随尿酸水平升高而增加。定期评估尿酸可为预测2型糖尿病患者的MS及预防动脉粥样硬化提供信息。
