Mokhtarian F
Maimonides Medical Center, Department of Medicine, Brooklyn, New York 11219.
Clin Immunol Immunopathol. 1988 Nov;49(2):308-17. doi: 10.1016/0090-1229(88)90121-3.
Acute and chronic relapsing forms of experimental allergic encephalomyelitis (EAE) can be induced in SJL/J mice following transfer of myelin basic protein (MBP)-sensitized T cells which have been challenged in vitro with MBP. In this study, addition of specific anti I-A antibody during the culture blocked the antigen-specific proliferation of T cells and inhibited the transfer of both acute and relapsing EAE. Treatment of T cell recipients with anti I-As antibody daily for 10 days suppressed the induction of acute EAE. Further treatment of mice with anti I-As antibody reduced the number of relapses and improved their conditions. We conclude that MBP-sensitized T cells interact with Ia positive cells, both in vitro and in vivo, to induce acute and chronic relapsing EAE, respectively. The mechanism of this interaction and its role in the disease process are discussed.
用髓磷脂碱性蛋白（MBP）致敏的T细胞在体外经MBP刺激后转移至SJL/J小鼠体内，可诱发实验性变应性脑脊髓炎（EAE）的急性和慢性复发形式。在本研究中，培养期间添加特异性抗I-A抗体可阻断T细胞的抗原特异性增殖，并抑制急性和复发性EAE的转移。用抗I-As抗体对T细胞受体小鼠连续治疗10天可抑制急性EAE的诱导。用抗I-As抗体对小鼠进一步治疗可减少复发次数并改善其状况。我们得出结论，MBP致敏的T细胞在体外和体内分别与Ia阳性细胞相互作用，以诱导急性和慢性复发性EAE。讨论了这种相互作用的机制及其在疾病过程中的作用。
