Sato S, Nakamura H, Takada K, Takahashi K
First Department of Internal Medicine, Yamagata University School of Medicine, Japan.
Eur Respir J. 1988 Jun;1(6):523-6.
We tested the hypothesis that a dietary supplement of vitamin E (VE) may lessen changes in pulmonary pressure-volume characteristics induced by intratracheal instillation of bleomycin. Ninety-nine male hamsters were separated into a control group (C), a VE supplement group (E), a control plus bleomycin group (CB) and a VE supplement plus bleomycin group (EB). Animals were killed at 30, 40, 55, 70 and 90 days and the pressure-volume curves of their lungs, both air-filled and saline-filled, were determined. Bleomycin was instilled on the thirtieth day. Lung volumes, compliance and curve-fitting data were compared. The mean serum VE concentration was 17.5 micrograms.ml-1 in groups E and EB as compared to 5.7 micrograms.ml-1 in groups C and CB. Despite the remarkably high VE content, no significant difference was found between groups CB and EB for the parameters compared.
膳食补充维生素E（VE）可能会减轻博来霉素气管内滴注引起的肺压力-容积特性变化。99只雄性仓鼠被分为对照组（C）、维生素E补充组（E）、对照组加博来霉素组（CB）和维生素E补充加博来霉素组（EB）。在第30、40、55、70和90天处死动物，测定其肺充气和充生理盐水时的压力-容积曲线。在第30天滴注博来霉素。比较肺容积、顺应性和曲线拟合数据。E组和EB组的平均血清VE浓度为17.5微克/毫升，而C组和CB组为5.7微克/毫升。尽管VE含量极高，但CB组和EB组之间比较的参数未发现显著差异。
