Semaphorin 3A：骨重塑中的新角色。
Semaphorin 3A: A new player in bone remodeling.
机构信息
Department of Orthopedic Surgery; Graduate School; Tokyo Medical and Dental University; Yushima, Bunkyo-ku, Tokyo, Japan; Global Center of Excellence (GCOE) Program; International Research Center for Molecular Science in Tooth and Bone Diseases; Tokyo Medical and Dental University, Tokyo, Japan.
出版信息
Cell Adh Migr. 2014;8(1):5-10. doi: 10.4161/cam.27752. Epub 2013 Jan 1.
Semaphorin 3A (Sema3A) is a protein identified originally as a diffusible axonal chemorepellent. Sema3A has multifunctional roles in embryonic development, immune regulation, vascularization, and oncogenesis. Bone remodeling consists of two phases: the removal of mineralized bone by osteoclasts and the formation of new bone by osteoblasts, and plays an essential role in skeletal diseases such as osteoporosis. Recent studies have shown that Sema3A is implicated in the regulation of osteoblastgenesis and osteoclastgenesis. Moreover, low bone mass in mice with specific knockout of Sema3A in the neurons indicates that Sema3A regulates bone remodeling indirectly. This review highlights recent advances on our understanding of the role of sema3A as a new player in the regulation of bone remodeling and proposes the potential of sema3A in the diagnosis and therapy of bone diseases.
神经纤毛蛋白 3A（Sema3A）最初被鉴定为一种可扩散的轴突化学排斥物，是一种蛋白质。Sema3A 在胚胎发育、免疫调节、血管生成和肿瘤发生中具有多种功能。骨重塑由两个阶段组成：破骨细胞去除矿化骨和成骨细胞形成新骨，在骨质疏松等骨骼疾病中起着重要作用。最近的研究表明，Sema3A 参与了成骨细胞和破骨细胞的生成调节。此外，神经元特异性敲除 Sema3A 的小鼠骨量减少表明 Sema3A 间接调节骨重塑。本综述强调了我们对 Sema3A 作为调节骨重塑的新因子的作用的最新认识，并提出了 Sema3A 在骨骼疾病的诊断和治疗中的潜在应用。
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