Tang Peifu, Yin Pengbin, Lv Houchen, Zhang Licheng, Zhang Lihai
Department of Orthopaedics, Chinese PLA General Hospital, Beijing China.
Crit Rev Eukaryot Gene Expr. 2015;25(1):47-57. doi: 10.1615/critreveukaryotgeneexpr.2015012469.
Semaphorin 3A (Sema3A), characterized by a conserved N-terminal "Sema" domain, was originally described as an axon guidance molecule. Recent research indicates that it performs a critical function in the skeletal system. This review highlights recent advances in understanding of the role of Sema3A in the skeletal system as a regulator of bone metabolism and as a potential drug target for bone disease therapy. We summarize Sema3A functions in osteoblastogenesis and osteoclastogenesis, as well as in innervation, and we discuss its multifunctional role in various bone diseases such as osteoporosis and low back pain. Despite limited research in this field, our aim is to promote further understanding of the function of Sema3A in the skeletal system.
信号素3A（Sema3A）以保守的N端“信号素”结构域为特征，最初被描述为一种轴突导向分子。最近的研究表明，它在骨骼系统中发挥着关键作用。本综述重点介绍了在理解Sema3A在骨骼系统中作为骨代谢调节剂和骨疾病治疗潜在药物靶点的作用方面的最新进展。我们总结了Sema3A在成骨细胞生成、破骨细胞生成以及神经支配中的功能，并讨论了其在骨质疏松症和腰痛等各种骨疾病中的多功能作用。尽管该领域的研究有限，但我们的目的是促进对Sema3A在骨骼系统中功能的进一步理解。
