Department of Neurology, Klinikum rechts der Isar, Technische Universität München, Germany.
Mult Scler. 2014 Mar;20(3):271-9. doi: 10.1177/1352458514522104.
The search for autoantibodies in multiple sclerosis (MS) has been challenging for the last 3 decades. With the development of new proteomic methods and advances in expression and assay technologies, progress in the identification of MS autoantibodies has been made. A number of MS-specific autoantibodies have been proposed, most of them targeting proteins expressed in oligodendrocytes and along the myelin sheath. In this review, we summarize the status of antibody research in MS and then discuss recent developments and future strategies in defining and characterizing the potential antigenic targets of autoantibodies in MS.
过去 30 年来，多发性硬化症（MS）自身抗体的研究一直颇具挑战性。随着新的蛋白质组学方法的发展以及表达和检测技术的进步，MS 自身抗体的鉴定工作取得了一定进展。目前已经提出了许多 MS 特异性自身抗体，其中大多数针对少突胶质细胞和髓鞘沿表达的蛋白质。在这篇综述中，我们总结了 MS 抗体研究的现状，然后讨论了定义和描述 MS 自身抗体潜在抗原靶标的最新进展和未来策略。
