发育与癌症中的从头 DNA 甲基转移酶 DNMT3A。
The de novo DNA methyltransferase DNMT3A in development and cancer.
机构信息
Chinese University of Hong Kong-Shandong University Joint Laboratory on Reproductive Genetics; School of Biomedical Sciences; Shenzhen Research Institute; the Chinese University of Hong Kong; Hong Kong SAR, PR China.
出版信息
Epigenetics. 2014 May;9(5):669-77. doi: 10.4161/epi.28324. Epub 2014 Mar 3.
Abstract
DNA methylation, one of the best-characterized epigenetic modifications, plays essential roles in development, aging and diseases. The de novo DNA methyltransferase DNMT3A is responsible for the establishment of de novo genomic DNA methylation patterns and, as such, involved in normal development as well as in many diseases including cancer. In recent years, our understanding of this important protein has made significant progress, which was facilitated by stunning development in the analysis of the DNA methylome of multiple organs and cell types. In this review, recent developments in the characterization of DNMT3A were discussed with special emphasis on the roles of DNMT3A in development and cancer.
摘要
DNA 甲基化是最典型的表观遗传修饰之一，在发育、衰老和疾病中起着至关重要的作用。从头甲基转移酶 DNMT3A 负责建立新的基因组 DNA 甲基化模式，因此参与正常发育以及包括癌症在内的许多疾病。近年来，对这种重要蛋白质的理解取得了重大进展，这得益于对多种器官和细胞类型的 DNA 甲基组进行分析的惊人发展。本综述讨论了 DNMT3A 特性的最新进展，特别强调了 DNMT3A 在发育和癌症中的作用。
相似文献
1
The de novo DNA methyltransferase DNMT3A in development and cancer.
Epigenetics. 2014 May;9(5):669-77. doi: 10.4161/epi.28324. Epub 2014 Mar 3.
2
Dnmt3a and Dnmt1 functionally cooperate during de novo methylation of DNA.
Eur J Biochem. 2002 Oct;269(20):4981-4. doi: 10.1046/j.1432-1033.2002.03198.x.
3
DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development.
Cell. 1999 Oct 29;99(3):247-57. doi: 10.1016/s0092-8674(00)81656-6.
4
The inherent processivity of the human de novo methyltransferase 3A (DNMT3A) is enhanced by DNMT3L.
J Biol Chem. 2010 Sep 17;285(38):29091-100. doi: 10.1074/jbc.M110.142513. Epub 2010 Jul 14.
5
Citrullination of DNMT3A by PADI4 regulates its stability and controls DNA methylation.
Nucleic Acids Res. 2014 Jul;42(13):8285-96. doi: 10.1093/nar/gku522. Epub 2014 Jun 23.
6
p53 and TDG are dominant in regulating the activity of the human de novo DNA methyltransferase DNMT3A on nucleosomes.
J Biol Chem. 2021 Jan-Jun;296:100058. doi: 10.1074/jbc.RA120.016125. Epub 2020 Nov 24.
7
Mutations in the DNMT3A DNA methyltransferase in acute myeloid leukemia patients cause both loss and gain of function and differential regulation by protein partners.
J Biol Chem. 2019 Mar 29;294(13):4898-4910. doi: 10.1074/jbc.RA118.006795. Epub 2019 Jan 31.
8
Synergistic function of DNA methyltransferases Dnmt3a and Dnmt3b in the methylation of Oct4 and Nanog.
Mol Cell Biol. 2007 Dec;27(24):8748-59. doi: 10.1128/MCB.01380-07. Epub 2007 Oct 15.
9
Identification of distinct loci for de novo DNA methylation by DNMT3A and DNMT3B during mammalian development.
Nat Commun. 2020 Jun 24;11(1):3199. doi: 10.1038/s41467-020-16989-w.
10
Preferential methylation of unmethylated DNA by Mammalian de novo DNA methyltransferase Dnmt3a.
J Biol Chem. 2002 Apr 5;277(14):11735-45. doi: 10.1074/jbc.M106590200. Epub 2002 Jan 30.
引用本文的文献
1
Unmasking the Epigenome: Insights into Testicular Cell Dynamics and Reproductive Function.
Int J Mol Sci. 2025 Jul 28;26(15):7305. doi: 10.3390/ijms26157305.
2
Chromatin modifiers in neurodevelopment.
Front Mol Neurosci. 2025 May 21;18:1551107. doi: 10.3389/fnmol.2025.1551107. eCollection 2025.
3
DNMT3A facilitates breast cancer progression via regulating ADAMTS8 mediated EGFR-MEK-ERK activation.
PLoS One. 2025 May 5;20(5):e0321889. doi: 10.1371/journal.pone.0321889. eCollection 2025.
4
Comparative epigenomics to clinical trials in human breast cancer and canine mammary tumor.
Anim Cells Syst (Seoul). 2025 Mar 19;29(1):12-30. doi: 10.1080/19768354.2025.2477024. eCollection 2025.
5
LINE-1 hypomethylation characterizes the inflammatory response in coeliac disease associated-intestinal mucosa and small bowel adenocarcinomas.
J Pathol. 2025 Jan;265(1):99-109. doi: 10.1002/path.6371. Epub 2024 Nov 27.
6
Molecular Basis of Hydatidiform Moles-A Systematic Review.
Int J Mol Sci. 2024 Aug 10;25(16):8739. doi: 10.3390/ijms25168739.
7
Identification of differentially expressed tumour-related genes regulated by UHRF1-driven DNA methylation.
Sci Rep. 2024 Aug 7;14(1):18371. doi: 10.1038/s41598-024-69110-2.
8
Structural basis for the H2AK119ub1-specific DNMT3A-nucleosome interaction.
Nat Commun. 2024 Jul 23;15(1):6217. doi: 10.1038/s41467-024-50526-3.
9
Fully equipped CARs to address tumor heterogeneity, enhance safety, and improve the functionality of cellular immunotherapies.
Front Immunol. 2024 Jun 3;15:1407992. doi: 10.3389/fimmu.2024.1407992. eCollection 2024.
10
Epigenetic modulation of cell fate during pancreas development.
Trends Dev Biol. 2023;16:1-27.
本文引用的文献
1
Aberrant DNA methylation in human cancers.
J Huazhong Univ Sci Technolog Med Sci. 2013 Dec;33(6):798-804. doi: 10.1007/s11596-013-1201-0. Epub 2013 Dec 13.
2
microRNA-199a-3p, DNMT3A, and aberrant DNA methylation in testicular cancer.
Epigenetics. 2014 Jan;9(1):119-28. doi: 10.4161/epi.25799. Epub 2013 Aug 19.
3
DNA methylation: roles in mammalian development.
Nat Rev Genet. 2013 Mar;14(3):204-20. doi: 10.1038/nrg3354. Epub 2013 Feb 12.
4
Cooperating gene mutations in childhood acute myeloid leukemia with special reference on mutations of ASXL1, TET2, IDH1, IDH2, and DNMT3A.
Blood. 2013 Apr 11;121(15):2988-95. doi: 10.1182/blood-2012-06-436782. Epub 2013 Jan 30.
5
DNMT3A mutations and clinical features in Chinese patients with acute myeloid leukemia.
Cancer Cell Int. 2013 Jan 11;13(1):1. doi: 10.1186/1475-2867-13-1.
6
Dnmt3a protects active chromosome domains against cancer-associated hypomethylation.
PLoS Genet. 2012;8(12):e1003146. doi: 10.1371/journal.pgen.1003146. Epub 2012 Dec 20.
7
DNMT3A Mutations in Patients with Acute Myeloid Leukemia in South Brazil.
Adv Hematol. 2012;2012:697691. doi: 10.1155/2012/697691. Epub 2012 Nov 8.
8
Mutations of the epigenetics-modifying gene (DNMT3a, TET2, IDH1/2) at diagnosis may induce FLT3-ITD at relapse in de novo acute myeloid leukemia.
Leukemia. 2013 Apr;27(5):1044-52. doi: 10.1038/leu.2012.317. Epub 2012 Nov 8.
9
Rescue of aging-associated decline in Dnmt3a2 expression restores cognitive abilities.
Nat Neurosci. 2012 Jul 1;15(8):1111-3. doi: 10.1038/nn.3151.
10
Mutations in the DNMT3A exon 23 independently predict poor outcome in older patients with acute myeloid leukemia: a SWOG report.
Leukemia. 2013 Jan;27(1):238-41. doi: 10.1038/leu.2012.168. Epub 2012 Jun 22.
Zotero 插件