Bes C, Altunrende B, Yılmaz Türkoğlu Ş, Yıldız N, Soy M
Department of Rheumatology Bakırköy Dr. Sadi Konuk Training and Research Hospital, İstanbul.
Department of Neurology, The Hospital of University of Abant Izzet Baysal, Bolu.
Clin Ter. 2014;165(1):19-21. doi: 10.7471/CT.2014.1655.
The incidences of extrapyramidal symptoms and Parkinson's disease were reported to be increased in patients with rheumatoid arthritis (RA). In this study we aimed to explore the frequency of the symptoms of Parkinsonism among RA patients older than 60 years.
30 (6 males, 24 females) consecutive RA patients, followed at a rheumatology outpatient clinic, who were 60 years of age or older; 23 patients who were diagnosed as PD and 50 sex and age matched healthy controls were included to the study. All participants were examined for the motor and non-motor findings of Parkinsonism including bradykinesia, rigidity, tremor, postural abnormality, upper limb sway abnormality, gait impairment, decrease in facial expression, seborrhea, slowing of speech and impairment in the self care.
When the RA, PD cases and healthy control group were compared for bradykinesia, rigidity, tremor, posture, upper limb sway, gait impairment, facial expression, seborrhea, speech and self care; highly significant differences were seen for all parameters. Two out of the 30 RA cases (6,7%) were diagnosed as Parkinson's disease.
The signs of Parkinsonism and Parkinson's disease were found more frequent in elderly RA cases as compared to healthy controls.
据报道，类风湿关节炎（RA）患者锥体外系症状和帕金森病的发病率有所增加。在本研究中，我们旨在探讨60岁以上RA患者帕金森综合征症状的发生频率。
连续纳入30例（6例男性，24例女性）在风湿病门诊随访的60岁及以上的RA患者；23例被诊断为帕金森病（PD）的患者以及50例年龄和性别匹配的健康对照者纳入本研究。对所有参与者进行帕金森综合征运动和非运动表现的检查，包括运动迟缓、僵硬、震颤、姿势异常、上肢摆动异常、步态障碍、面部表情减少、皮脂溢、言语迟缓以及自我照料能力受损。
比较RA组、PD组和健康对照组在运动迟缓、僵硬、震颤、姿势、上肢摆动、步态障碍、面部表情、皮脂溢、言语和自我照料方面的情况；所有参数均存在高度显著差异。30例RA患者中有2例（6.7%）被诊断为帕金森病。
与健康对照组相比，老年RA患者中帕金森综合征和帕金森病的体征更为常见。
