Vogel G, Markwardt F
Department of Haemostaseology, Medical Academy Erfurt, GDR.
Folia Haematol Int Mag Klin Morphol Blutforsch. 1988;115(1-2):113-8.
The pharmacokinetics and the effects on the haemostatic system of hirudin were assessed in healthy volunteers after single doses of 1,000 AT-U/kg administered intravenously respectively subcutaneously. First clinical experiences on hirudin treatment in chronic DIC are reported.
在健康志愿者中分别静脉注射和皮下注射1000抗凝血酶单位/千克单剂量水蛭素后，评估了水蛭素的药代动力学及其对止血系统的影响。报告了水蛭素治疗慢性弥散性血管内凝血的首批临床经验。
