Tan D P, Tsou K
Shanghai Institute of Materia Medica, Chinese Academy of Sciences.
J Neurochem. 1988 Nov;51(5):1333-7. doi: 10.1111/j.1471-4159.1988.tb01093.x.
The effects of intranigral injection of kassinin, eledoisin, and substance P on striatal dopamine (DA) and 3,4-dihydroxyphenylacetic acid (DOPAC) contents as well as circling behavior were studied in rats. Kassinin and eledoisin produced a marked dose-dependent increase of DOPAC concentrations in the ipsilateral striatum, as well as in the number of contralateral circlings. Substance P produced a similar but weaker effect. At the larger dose (5 nmol), the three tachykinins also induced an increase of DA concentrations in the ipsilateral striatum. The rank order of activity was kassinin greater than eledoisin greater than substance P. These results suggest that tachykinins stimulated the nigro-striatal dopaminergic system by accelerating the dopamine metabolism in striatum.
研究了向大鼠黑质内注射蛙皮素、eledoisin和P物质对纹状体多巴胺（DA）和3,4-二羟基苯乙酸（DOPAC）含量以及转圈行为的影响。蛙皮素和eledoisin使同侧纹状体中DOPAC浓度显著呈剂量依赖性增加，同时使对侧转圈次数增加。P物质产生了类似但较弱的作用。在较大剂量（5 nmol）时，这三种速激肽还诱导同侧纹状体中DA浓度增加。活性顺序为蛙皮素大于eledoisin大于P物质。这些结果表明，速激肽通过加速纹状体中的多巴胺代谢来刺激黑质-纹状体多巴胺能系统。
