Muraki Shigeyuki, Akune Toru, Nagata Keiji, Ishimoto Yuyu, Yoshida Munehito, Tokimura Fumiaki, Tanaka Sakae, Oka Hiroyuki, Kawaguchi Hiroshi, Nakamura Kozo, Yoshimura Noriko
Department of Clinical Motor System Medicine, 22nd Century Medical & Research Center, Faculty of Medicine, the University of Tokyo , Tokyo , Japan.
Mod Rheumatol. 2014 Nov;24(6):966-73. doi: 10.3109/14397595.2014.883055. Epub 2014 Mar 4.
To examine the onset and resolution of pain and physical functional disability using Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and their association with knee osteoarthritis (OA) in the longitudinal large-scale population of the nationwide cohort study, Research on Osteoarthritis/osteoporosis Against Disability (ROAD).
Subjects from the ROAD study who had been recruited during 2005-2007 were followed up 3 years later. A total of 1,578 subjects completed the WOMAC questionnaire at baseline and follow up, and the onset and resolution rate of pain and physical functional disability were examined. We also examined the association of onset of pain and physical functional disability and their resolution with severity of knee OA as well as age, body-mass index and grip strength.
After a 3.3-year follow-up, the onset rate of pain was 35.0% and 35.3% in men and women, respectively, and the onset rate of physical functional disability was 38% and 40%, respectively. Resolution rate of pain was 20.3% and 26.2% in men and women, respectively, and resolution rate of physical functional disability was 16% and 14% in men and women, respectively. Knee OA was significantly associated with onset and resolution of pain and physical functional disability in women, but there was no significant association of knee OA with onset of pain and resolution of physical functional disability in men.
The present longitudinal study revealed the onset rate of pain and physical functional disability as well as their resolution, and their association with knee OA.
在全国性队列研究“骨关节炎/骨质疏松症与残疾研究（ROAD）”的纵向大规模人群中，使用西安大略和麦克马斯特大学骨关节炎指数（WOMAC）来研究疼痛和身体功能障碍的发生及缓解情况，以及它们与膝关节骨关节炎（OA）的关联。
对2005 - 2007年招募的ROAD研究受试者进行3年后的随访。共有1578名受试者在基线和随访时完成了WOMAC问卷，研究了疼痛和身体功能障碍的发生率及缓解率。我们还研究了疼痛和身体功能障碍的发生及其缓解与膝关节OA严重程度以及年龄、体重指数和握力的关联。
经过3.3年的随访，男性和女性的疼痛发生率分别为35.0%和35.3%，身体功能障碍发生率分别为38%和40%。男性和女性的疼痛缓解率分别为20.3%和26.2%，身体功能障碍缓解率分别为16%和14%。膝关节OA与女性疼痛和身体功能障碍的发生及缓解显著相关，但与男性疼痛的发生和身体功能障碍的缓解无显著关联。
本纵向研究揭示了疼痛和身体功能障碍的发生率及其缓解情况，以及它们与膝关节OA的关联。
