Sorimachi M, Nishimura S, Yamagami K, Yada T
Department of Physiology, Kagoshima University, School of Medicine, Japan.
Jpn J Physiol. 1988;38(2):227-32. doi: 10.2170/jjphysiol.38.227.
The combination of NaF and AlCl3 stimulated histamine secretion from digitonin-permeabilized rat mast cells only in the presence of trace amount of Ca2+. When NaF plus AlCl3 were added together with a maximal dose of guanosine-5'-[gamma-thio]triphosphate (GTP gamma S), the combined effect was less than additive. The results suggest that the secretory effect of fluoroaluminates is, at least partially, mediated by GTP-binding protein, which is previously found to be activated by GTP gamma S.
仅在存在微量Ca2+的情况下，氟化钠（NaF）和氯化铝（AlCl3）的组合才会刺激经洋地黄皂苷通透处理的大鼠肥大细胞分泌组胺。当NaF与AlCl3与最大剂量的鸟苷-5'-[γ-硫代]三磷酸（GTPγS）一起添加时，联合效应小于相加效应。结果表明，氟铝酸盐的分泌效应至少部分是由GTP结合蛋白介导的，此前发现该蛋白可被GTPγS激活。
