氟铝酸盐在激活肝细胞膜的多磷酸肌醇磷酸二酯酶方面模拟鸟苷5'-[γ-硫代]三磷酸。鸟嘌呤核苷酸调节蛋白Gp在信号转导中的作用。
Fluoroaluminates mimic guanosine 5'-[gamma-thio]triphosphate in activating the polyphosphoinositide phosphodiesterase of hepatocyte membranes. Role for the guanine nucleotide regulatory protein Gp in signal transduction.
作者信息
Cockcroft S, Taylor J A
出版信息
Biochem J. 1987 Jan 15;241(2):409-14. doi: 10.1042/bj2410409.
Abstract
Fluoride and guanosine 5'-[gamma-thio]triphosphate (GTP gamma S) both activate the hepatocyte membrane polyphosphoinositide phosphodiesterase (PPI-pde) in a concentration-dependent manner. AlCl3 enhances the fluoride effect, supporting the concept that [A1F4]- is the active species. Analysis of the products of inositol lipid hydrolysis demonstrate that phosphatidylinositol bisphosphate is the major lipid to be hydrolysed. Guanosine 5'-[beta-thio]diphosphate (GDP beta S) is an inhibitor of activation of PPI-pde by both fluoride and GTP gamma S. These observations suggest that the guanine nucleotide regulatory protein (termed Gp) bears a structural resemblance to the well-characterized G-proteins of the adenylate cyclase system and the cyclic GMP phosphodiesterase system in phototransduction.
摘要
氟化物和鸟苷5'-[γ-硫代]三磷酸（GTPγS）均以浓度依赖的方式激活肝细胞膜多磷酸肌醇磷酸二酯酶（PPI-pde）。AlCl3增强氟化物的作用，支持[A1F4]-是活性物质的概念。对肌醇脂质水解产物的分析表明，磷脂酰肌醇二磷酸是主要被水解的脂质。鸟苷5'-[β-硫代]二磷酸（GDPβS）是氟化物和GTPγS激活PPI-pde的抑制剂。这些观察结果表明，鸟嘌呤核苷酸调节蛋白（称为Gp）在结构上与腺苷酸环化酶系统和光转导中的环鸟苷酸磷酸二酯酶系统中特征明确的G蛋白相似。
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本文引用的文献
1
The dependence on Ca2+ of phosphatidylinositol breakdown and enzyme secretion in rabbit neutrophils stimulated by formylmethionyl-leucylphenylalanine or ionomycin.甲酰甲硫氨酰-亮氨酰-苯丙氨酸或离子霉素刺激的兔中性粒细胞中磷脂酰肌醇分解和酶分泌对Ca2+的依赖性。
Biochem J. 1981 Dec 15;200(3):501-8. doi: 10.1042/bj2000501.
2
Fluoride stimulation of canine neutrophils: the role of calcium binding.氟化物对犬中性粒细胞的刺激作用：钙结合的作用
Proc Soc Exp Biol Med. 1982 Jul;170(3):333-40. doi: 10.3181/00379727-170-41439.
3
Homologies between signal transducing G proteins and ras gene products.信号转导G蛋白与ras基因产物之间的同源性。
Science. 1984 Nov 16;226(4676):860-2. doi: 10.1126/science.6436980.
4
Transducin and the cyclic GMP phosphodiesterase: amplifier proteins in vision.转导素与环鸟苷酸磷酸二酯酶：视觉中的放大蛋白。
Cold Spring Harb Symp Quant Biol. 1983;48 Pt 2:841-52. doi: 10.1101/sqb.1983.048.01.087.
5
G proteins and dual control of adenylate cyclase.G蛋白与腺苷酸环化酶的双重调控
Cell. 1984 Mar;36(3):577-9. doi: 10.1016/0092-8674(84)90336-2.
6
Chemical excitation of Limulus photoreceptors. II. Vanadate, GTP-gamma-S, and fluoride prolong excitation evoked by dim flashes of light.鲎光感受器的化学激发。II. 钒酸盐、鸟苷-5'-三磷酸γ-硫酯和氟化物可延长弱闪光诱发的激发。
J Gen Physiol. 1983 Nov;82(5):659-77. doi: 10.1085/jgp.82.5.659.
7
Chemical excitation of Limulus photoreceptors. I. Phosphatase inhibitors induce discrete-wave production in the dark.鲎光感受器的化学激发。I. 磷酸酶抑制剂在黑暗中诱导离散波产生。
J Gen Physiol. 1983 Nov;82(5):639-57. doi: 10.1085/jgp.82.5.639.
8
Rapid breakdown of phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate in rat hepatocytes stimulated by vasopressin and other Ca2+-mobilizing hormones.血管加压素和其他可动员钙离子的激素刺激下大鼠肝细胞中磷脂酰肌醇4-磷酸和磷脂酰肌醇4,5-二磷酸的快速分解。
Biochem J. 1983 Jun 15;212(3):733-47. doi: 10.1042/bj2120733.
9
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10
Aluminum: a requirement for activation of the regulatory component of adenylate cyclase by fluoride.铝：氟化物激活腺苷酸环化酶调节成分所必需的物质。
Proc Natl Acad Sci U S A. 1982 Aug;79(16):4888-91. doi: 10.1073/pnas.79.16.4888.
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