磷脂酶 C epsilon 1 多态性与癌症风险的荟萃分析。

Meta-analysis of phospholipase C epsilon 1 polymorphism and cancer risk.

机构信息

Institute of Stomatology, Nanjing Medical University, Nanjing, China.

Education and Scientific Research Department, Huai'an First People's Hospital, Nanjing Medical University, Huai'an, Jiangsu, China.

出版信息

Cancer Biomark. 2013 Jan 1;13(6):483-9. doi: 10.3233/CBM-130388.

DOI:10.3233/CBM-130388

PMID:24595086

Abstract

BACKGROUND

Phospholipase C epsilon 1 (PLCE1) plays crucial roles in carcinogenesis and progression of several cancers. A single nucleotide polymorphism (SNP, rs2274223) in PLCE1 has been identified as a novel susceptibility locus.

METHODS

To evaluate the role of the Phospholipase C epsilon 1 (PLCE1) polymorphism in cancer susceptibility. We performed a meta-analysis of all available studies, including 8,689 cases and 10,794 controls to derive a more precise relationship. An odds ratio (OR) with a 95% confidence interval (CI) was applied to assess the association between PLCE1 rs2274223 polymorphism and cancer risk.

RESULTS

A total of 14 case-control studies were included in the present meta-analysis. Overall significant associations were observed (AG vs. AA: OR=1.17, 95%CI=1.04-1.31; GG vs. AA: OR=1.32, 95%CI=1.06-1.66; AG/GG vs. AA: OR=1.19, 95%CI=1.05-1.34; G vs. A: OR=1.16, 95%CI=1.04-1.29) in all cancer types. In the subgroup analysis, PLCE1 rs2274223 polymorphism was significantly increased risk of cancer in Chinese population by ethnicity and upper aerodigestive tract cancer by cancer types.

CONCLUSIONS

Our meta-analysis suggested the PLCE1 rs2274223 might act as a cancer risk factor among all subjects, especially in the Chinese population and upper aerodigestive tract cancer.

摘要

背景

磷酯酶 C ɛ 1（PLCE1）在多种癌症的发生和进展中起着至关重要的作用。PLCE1 中的单核苷酸多态性（SNP，rs2274223）已被确定为新的易感性位点。

方法

为了评估磷酯酶 C ɛ 1（PLCE1）多态性在癌症易感性中的作用。我们对所有可用的研究进行了荟萃分析，包括 8689 例病例和 10794 例对照，以得出更精确的关系。应用比值比（OR）和 95％置信区间（CI）来评估 PLCE1 rs2274223 多态性与癌症风险之间的关联。

结果

本荟萃分析共纳入了 14 项病例对照研究。总体观察到显著相关性（AG 与 AA：OR=1.17，95％CI=1.04-1.31；GG 与 AA：OR=1.32，95％CI=1.06-1.66；AG/GG 与 AA：OR=1.19，95％CI=1.05-1.34；G 与 A：OR=1.16，95％CI=1.04-1.29）。在亚组分析中，根据种族和癌症类型，PLCE1 rs2274223 多态性与癌症风险显著相关。