Xue Wenji, Zhu Meiling, Wang Yiwei, He Jing, Zheng Leizhen
Department of Oncology, Xin Hua Hospital affiliated To Shanghai Jiaotong University School of Medicine, Shanghai 200092, Shanghai, China.
State Key Laboratory of Oncology in South China, Department of Experimental Research, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou 510060, Guangdong, China.
Sci Rep. 2015 Jan 23;5:7986. doi: 10.1038/srep07986.
Phospholipase C epsilon 1 (PLCE1) plays an important role in cell growth, differentiation and oncogenesis. An increasing number of individual studies have investigated the association between PLCE1 rs2274223 polymorphism and cancer risk, but the conclusions are inconclusive. To obtain a comprehensive conclusion, we performed a meta-analysis of 22 studies with 13188 cases and 14666 controls. The pooled results indicated that PLCE1 rs2274223 A > G polymorphism was associated with an increased risk of overall cancer (G vs. A: OR = 1.15, 95% CI = 1.06-1.25; GG vs. AA: OR = 1.30, 95% CI = 1.10-1.55; GA vs. AA: OR = 1.18, 95% CI = 1.08-1.30; GG/GA vs. AA: OR = 1.20, 95% CI = 1.08-1.32; GG vs.
GA/AA: OR = 1.22, 95% CI = 1.04-1.42). The stratification analysis showed the polymorphism was significantly associated with an increased risk of esophageal squamous cell carcinoma (ESCC) other than gastric cancer (GC), especially among the subgroups of Asian, high quality score, sample size > 1000 and the studies consistent with Hardy-Weinberg equilibrium (HWE). This meta-analysis demonstrated that PLCE1 rs2274223 A > G polymorphism may be associated with increased susceptibility to cancer, especially for ESCC. However, due to the substantial heterogeneities across the studies, the conclusion might be not conclusive that need more studies to confirm.
磷脂酶Cε1（PLCE1）在细胞生长、分化和肿瘤发生中起重要作用。越来越多的个体研究调查了PLCE1 rs2274223多态性与癌症风险之间的关联，但结论尚无定论。为得出全面结论，我们对22项研究进行了荟萃分析，这些研究涉及13188例病例和14666例对照。汇总结果表明，PLCE1 rs2274223 A>G多态性与总体癌症风险增加相关（G vs. A：比值比=1.15，95%置信区间=1.06-1.25；GG vs. AA：比值比=1.30，95%置信区间=1.10-1.55；GA vs. AA：比值比=1.18，95%置信区间=1.08-1.30；GG/GA vs. AA：比值比=1.20，95%置信区间=1.08-1.32；GG vs. GA/AA：比值比=1.22，95%置信区间=1.04-1.42）。分层分析显示，该多态性与食管癌（ESCC）风险增加显著相关，而非胃癌（GC），特别是在亚洲亚组、高质量评分、样本量>1000以及符合哈迪-温伯格平衡（HWE）的研究中。这项荟萃分析表明，PLCE1 rs2274223 A>G多态性可能与癌症易感性增加相关，尤其是对于ESCC。然而，由于各研究间存在较大异质性，该结论可能尚无定论，需要更多研究来证实。
