van der Starre P J, Reneman R S
Department of Anesthesiology, Medical Center De Klokkenberg, Breda, The Netherlands.
J Cardiovasc Pharmacol. 1988;11 Suppl 1:S54-61.
The alpha 1-adrenergic receptor blocking effect of ketanserin, the blocking properties of this compound for nonspecific stimulation with angiotensin II, and the alpha-adrenergic receptor blocking properties and the blood pressure lowering effect of phentolamine, ritanserin, and the combination of both compounds were studied in patients on cardiopulmonary bypass (constant flow rate, mild hypothermia) undergoing coronary artery bypass grafting. Phenylephrine was used as alpha 1-adrenergic agonist. Ketanserin reduces the alpha 1-agonistic effect of phenylephrine on blood pressure in a dose-dependent manner up to a dose of 10 mg. Ketanserin did not block the nonspecific vasoconstriction, as induced by angiotensin II. The moderate blood pressure lowering effect of phentolamine was substantially potentiated by ritanserin, which in itself did not affect blood pressure. The findings in this study indicate that the blood pressure lowering activity of ketanserin results from a combined blockade of alpha 1-adrenergic and S2-serotonergic receptors.
在接受冠状动脉搭桥术的体外循环（恒流率，轻度低温）患者中，研究了酮色林的α1-肾上腺素能受体阻断作用、该化合物对血管紧张素II非特异性刺激的阻断特性，以及酚妥拉明、利坦色林及其两者组合的α-肾上腺素能受体阻断特性和降压作用。去氧肾上腺素用作α1-肾上腺素能激动剂。酮色林以剂量依赖性方式降低去氧肾上腺素对血压的α1-激动作用，最大剂量达10 mg。酮色林未阻断血管紧张素II诱导的非特异性血管收缩。利坦色林显著增强了酚妥拉明的中度降压作用，而利坦色林本身不影响血压。本研究结果表明，酮色林的降压活性源于α1-肾上腺素能受体和S2-血清素能受体的联合阻断。
