钯催化β-烯胺羰基化合物与烯丙基双乙酸酯的环化反应合成功能化的 2-乙烯基-2,3-二氢吡咯和 3-亚甲基-1,2,3,4-四氢吡啶。
Synthesis of functionalized 2-vinyl-2,3-dihydropyrroles and 3-methylene-1,2,3,4-tetrahydropyridines by palladium-catalyzed cyclization of β-enaminocarbonyl compounds with allylic bisacetates.
机构信息
Graduate School of Pharmaceutical Sciences, The University of Tokushima, 1-78-1 Sho-machi, Tokushima 770-8505, Japan.
出版信息
Org Biomol Chem. 2014 Apr 21;12(15):2394-403. doi: 10.1039/c3ob42510j.
PMID:24595409
Abstract
A palladium-catalyzed cyclization of β-enaminocarbonyl compounds with allylic bisacetates is described. 2-Vinyl-2,3-dihydropyrroles and 3-methylene-1,2,3,4-tetrahydropyridines were produced from the reaction of β-enaminocarbonyl compounds with 1,4-diacetoxy-2-butene and 2-methylene-1,3-propanediol diacetate, respectively.
摘要
钯催化的β-烯胺羰基化合物与烯丙基双乙酸酯的环化反应被描述。β-烯胺羰基化合物与 1,4-二乙酰氧基-2-丁烯和 2-亚甲基-1,3-丙二醇二乙酸酯反应，分别生成 2-乙烯基-2,3-二氢吡咯和 3-亚甲基-1,2,3,4-四氢吡啶。
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