• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

金属介导的吡咯啉合成。

Metal-mediated synthesis of pyrrolines.

作者信息

Medran Noelia S, La-Venia Agustina, Testero Sebastian A

机构信息

Instituto de Química Rosario - IQUIR (CONICET), Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario Suipacha 531 Rosario S2002LRK Argentina

出版信息

RSC Adv. 2019 Feb 27;9(12):6804-6844. doi: 10.1039/c8ra10247c. eCollection 2019 Feb 22.

DOI:10.1039/c8ra10247c
PMID:35518475
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9061060/
Abstract

The five-membered, nitrogen-containing pyrroline ring is a privileged structure. This ring is present in many bioactive compounds from natural sources. Pyrrolines-the dihydro derivatives of pyrroles-have three structural isomer classes, depending on the location of the double bond: 1-pyrrolines (3,4-dihydro-2-pyrroles), 2-pyrrolines (2,3-dihydro-1-pyrroles) and 3-pyrrolines (2,5-dihydro-1-pyrroles). This review aims to describe the latest advances for the synthesis of pyrrolines by transition metal-catalyzed cyclizations. Only reactions in which the pyrroline ring is formed by metal promotion are described. Transformations of the pyrroline ring in other heterocycles, and the structural manipulations of the pyrroline itself are not discussed. The review is organized into three parts, each covering the metal-mediated synthesis of the three pyrroline isomers. Each part is subdivided according to the metal involved, and concludes with a brief description of notable biological activities within the class.

摘要

五元含氮吡咯啉环是一种优势结构。该环存在于许多天然来源的生物活性化合物中。吡咯啉（吡咯的二氢衍生物）有三类结构异构体，取决于双键的位置：1-吡咯啉（3,4-二氢-2-吡咯）、2-吡咯啉（2,3-二氢-1-吡咯）和3-吡咯啉（2,5-二氢-1-吡咯）。本综述旨在描述过渡金属催化环化合成吡咯啉的最新进展。仅描述通过金属促进形成吡咯啉环的反应。不讨论吡咯啉环在其他杂环中的转化以及吡咯啉本身的结构操作。本综述分为三个部分，每个部分涵盖三种吡咯啉异构体的金属介导合成。每个部分根据所涉及的金属进行细分，并以该类别内显著生物活性的简要描述作为结尾。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65dc/9061060/3fe94d9032e4/c8ra10247c-p2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65dc/9061060/794bd0781800/c8ra10247c-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65dc/9061060/a7f47f4ae5fd/c8ra10247c-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65dc/9061060/4280c92e4c2e/c8ra10247c-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65dc/9061060/76deccdeccc5/c8ra10247c-s2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65dc/9061060/0d3c05e980b5/c8ra10247c-s3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65dc/9061060/0bb935048517/c8ra10247c-s4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65dc/9061060/344fe1ac07c0/c8ra10247c-s5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65dc/9061060/df3d1dc2eecc/c8ra10247c-s6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65dc/9061060/8cbbed7650a6/c8ra10247c-s7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65dc/9061060/a2979c32502d/c8ra10247c-s8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65dc/9061060/aa995909effc/c8ra10247c-s9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65dc/9061060/f145b590b375/c8ra10247c-s10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65dc/9061060/be23ac5b1cb3/c8ra10247c-s11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65dc/9061060/46c58fc6b678/c8ra10247c-s12.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65dc/9061060/a7ecb650e87e/c8ra10247c-s13.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65dc/9061060/3d7dd4a297bc/c8ra10247c-s14.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65dc/9061060/ca0ee8b29b36/c8ra10247c-s15.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65dc/9061060/8b35e2593487/c8ra10247c-s16.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65dc/9061060/939b1740e429/c8ra10247c-s17.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65dc/9061060/46080a7a38f4/c8ra10247c-s18.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65dc/9061060/a5cab37aaeed/c8ra10247c-s19.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65dc/9061060/ce828ae54a6a/c8ra10247c-s20.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65dc/9061060/63e2a977e716/c8ra10247c-s21.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65dc/9061060/b601d7e116d7/c8ra10247c-s22.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65dc/9061060/f83f8b26703d/c8ra10247c-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65dc/9061060/3c184aa1513c/c8ra10247c-s23.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65dc/9061060/4564c0e116b2/c8ra10247c-s24.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65dc/9061060/ff431353d4a4/c8ra10247c-s25.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65dc/9061060/864b70d00ed3/c8ra10247c-s26.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65dc/9061060/8a100152f46c/c8ra10247c-s27.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65dc/9061060/ebadffa28bf8/c8ra10247c-s28.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65dc/9061060/803c0eafa0b4/c8ra10247c-s29.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65dc/9061060/0bd9b6d730a3/c8ra10247c-s30.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65dc/9061060/56ade0e54516/c8ra10247c-s31.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65dc/9061060/718a10e6bdb6/c8ra10247c-s32.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65dc/9061060/7b9ac3383b7a/c8ra10247c-s33.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65dc/9061060/fce7540f02e1/c8ra10247c-s34.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65dc/9061060/dc688f6990aa/c8ra10247c-s35.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65dc/9061060/8cf1693c1673/c8ra10247c-s36.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65dc/9061060/381ed7ed24de/c8ra10247c-s130.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65dc/9061060/c520f45c4644/c8ra10247c-s135.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65dc/9061060/4adfadfa5f5f/c8ra10247c-p1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65dc/9061060/3fe94d9032e4/c8ra10247c-p2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65dc/9061060/794bd0781800/c8ra10247c-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65dc/9061060/a7f47f4ae5fd/c8ra10247c-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65dc/9061060/4280c92e4c2e/c8ra10247c-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65dc/9061060/76deccdeccc5/c8ra10247c-s2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65dc/9061060/0d3c05e980b5/c8ra10247c-s3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65dc/9061060/0bb935048517/c8ra10247c-s4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65dc/9061060/344fe1ac07c0/c8ra10247c-s5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65dc/9061060/df3d1dc2eecc/c8ra10247c-s6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65dc/9061060/8cbbed7650a6/c8ra10247c-s7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65dc/9061060/a2979c32502d/c8ra10247c-s8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65dc/9061060/aa995909effc/c8ra10247c-s9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65dc/9061060/f145b590b375/c8ra10247c-s10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65dc/9061060/be23ac5b1cb3/c8ra10247c-s11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65dc/9061060/46c58fc6b678/c8ra10247c-s12.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65dc/9061060/a7ecb650e87e/c8ra10247c-s13.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65dc/9061060/3d7dd4a297bc/c8ra10247c-s14.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65dc/9061060/ca0ee8b29b36/c8ra10247c-s15.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65dc/9061060/8b35e2593487/c8ra10247c-s16.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65dc/9061060/939b1740e429/c8ra10247c-s17.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65dc/9061060/46080a7a38f4/c8ra10247c-s18.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65dc/9061060/a5cab37aaeed/c8ra10247c-s19.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65dc/9061060/ce828ae54a6a/c8ra10247c-s20.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65dc/9061060/63e2a977e716/c8ra10247c-s21.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65dc/9061060/b601d7e116d7/c8ra10247c-s22.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65dc/9061060/f83f8b26703d/c8ra10247c-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65dc/9061060/3c184aa1513c/c8ra10247c-s23.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65dc/9061060/4564c0e116b2/c8ra10247c-s24.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65dc/9061060/ff431353d4a4/c8ra10247c-s25.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65dc/9061060/864b70d00ed3/c8ra10247c-s26.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65dc/9061060/8a100152f46c/c8ra10247c-s27.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65dc/9061060/ebadffa28bf8/c8ra10247c-s28.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65dc/9061060/803c0eafa0b4/c8ra10247c-s29.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65dc/9061060/0bd9b6d730a3/c8ra10247c-s30.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65dc/9061060/56ade0e54516/c8ra10247c-s31.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65dc/9061060/718a10e6bdb6/c8ra10247c-s32.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65dc/9061060/7b9ac3383b7a/c8ra10247c-s33.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65dc/9061060/fce7540f02e1/c8ra10247c-s34.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65dc/9061060/dc688f6990aa/c8ra10247c-s35.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65dc/9061060/8cf1693c1673/c8ra10247c-s36.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65dc/9061060/381ed7ed24de/c8ra10247c-s130.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65dc/9061060/c520f45c4644/c8ra10247c-s135.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65dc/9061060/4adfadfa5f5f/c8ra10247c-p1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65dc/9061060/3fe94d9032e4/c8ra10247c-p2.jpg

相似文献

1
Metal-mediated synthesis of pyrrolines.金属介导的吡咯啉合成。
RSC Adv. 2019 Feb 27;9(12):6804-6844. doi: 10.1039/c8ra10247c. eCollection 2019 Feb 22.
2
Synthesis and antineoplastic activity of bis[[[(alkylamino)carbonyl]oxy]methyl]-substituted 3-pyrrolines as prodrugs of tumor inhibitory pyrrole bis(carbamates).双[[[(烷基氨基)羰基]氧基]甲基]取代的3-吡咯啉作为肿瘤抑制性吡咯双(氨基甲酸酯)前药的合成及其抗肿瘤活性
J Med Chem. 1986 Nov;29(11):2241-9. doi: 10.1021/jm00161a019.
3
Synthesis of 3-pyrrolines, annulated 3-pyrrolines, and pyrroles from alpha-amino allenes.由α-氨基联烯合成3-吡咯啉、稠合3-吡咯啉和吡咯。
Org Lett. 2001 Nov 29;3(24):3855-8. doi: 10.1021/ol016654+.
4
Synthesis of novel 5-alkyl/aryl/heteroaryl substituted diethyl 3,4-dihydro-2H-pyrrole-4,4-dicarboxylates by aziridine ring expansion of 2-[(aziridin-1-yl)-1-alkyl/aryl/heteroaryl-methylene]malonic acid diethyl esters.通过氮丙啶环扩张 2-[(氮丙啶-1-基)-1-烷基/芳基/杂芳基亚甲基]丙二酸二乙酯合成新型 5-烷基/芳基/杂芳基取代的二乙基 3,4-二氢-2H-吡咯-4,4-二羧酸酯。
Beilstein J Org Chem. 2011;7:831-8. doi: 10.3762/bjoc.7.95. Epub 2011 Jun 20.
5
2-Trimethylsilylethanesulfonyl (SES) versus tosyl (Ts) protecting group in the preparation of nitrogen-containing five-membered rings. A novel route for the synthesis of substituted pyrrolines and pyrrolidines.在含氮五元环制备中2-三甲基硅基乙磺酰基（SES）与对甲苯磺酰基（Ts）保护基的比较。一种合成取代吡咯啉和吡咯烷的新途径。
J Org Chem. 2007 Feb 16;72(4):1518-21. doi: 10.1021/jo062239p.
6
An atom efficient route to N-aryl and N-alkyl pyrrolines by transition metal catalysis.通过过渡金属催化实现原子经济性的 N-芳基和 N-烷基吡咯啉合成方法。
Org Biomol Chem. 2011 Apr 7;9(7):2548-54. doi: 10.1039/c0ob00383b. Epub 2011 Feb 22.
7
Nickel-Catalyzed Enantioselective Synthesis of 2,3,4-Trisubstituted 3-Pyrrolines.镍催化的手性 2,3,4-三取代 3-吡咯啉的合成。
Angew Chem Int Ed Engl. 2022 Jul 18;61(29):e202203494. doi: 10.1002/anie.202203494. Epub 2022 May 17.
8
Synthesis of 1-pyrroline derivatives cyclization of terminal alkynes with 2-azaallyls.1-吡咯啉衍生物的合成——末端炔烃与 2-氮杂烯丙基的环化反应。
Org Biomol Chem. 2022 Apr 6;20(14):2843-2851. doi: 10.1039/d2ob00102k.
9
Stereoselective synthesis of highly substituted Delta1-pyrrolines: exo-selective 1,3-dipolar cycloaddition reactions with azlactones.高取代Δ1-吡咯啉的立体选择性合成：与恶唑酮的外型选择性1,3-偶极环加成反应。
J Am Chem Soc. 2004 Oct 13;126(40):12776-7. doi: 10.1021/ja046149i.
10
Tunable Zinc-Mediated Reductive Cyclization of Diastereomeric 3-Nitro-4-phenacyl-2-(trihalomethyl)chromanes to Fused Pyrroline -Oxides, Pyrrolines, and Pyrrolidines.可调谐锌介导的非对映异构3-硝基-4-苯甲酰基-2-（三卤甲基）色满向稠合吡咯啉-氧化物、吡咯啉和吡咯烷的还原环化反应。
J Org Chem. 2024 Feb 2;89(3):1567-1590. doi: 10.1021/acs.joc.3c02191. Epub 2024 Jan 20.

引用本文的文献

1
Synthesis and Evaluation of the Antiproliferative Activity of the Derivatives of 3,5-Diaryl-3,4-dihydro-2-pyrrole-2-carboxylic Acids.3,5-二芳基-3,4-二氢-2-吡咯-2-羧酸衍生物的合成及其抗增殖活性评估
Molecules. 2025 Apr 3;30(7):1602. doi: 10.3390/molecules30071602.
2
Cyclic Bifunctional Reagents Enabling a Strain-Release-Driven Formal [3 + 2] Cycloaddition of 2-Azirines by Cascade Energy Transfer.通过级联能量转移实现应变释放驱动的2-氮杂环丙烷的形式[3 + 2]环加成的环状双功能试剂。
J Am Chem Soc. 2025 Apr 23;147(16):13276-13285. doi: 10.1021/jacs.4c18080. Epub 2025 Apr 10.
3
Investigating the thin film growth of [Ni(Hvanox)] by microscopic and spectroscopic techniques.

本文引用的文献

1
In Situ-Generated Niobium-Catalyzed Synthesis of 3-Pyrroline Derivatives via Ring-Closing Metathesis Reactions.原位生成铌催化通过关环复分解反应合成3-吡咯啉衍生物
ACS Omega. 2018 Aug 9;3(8):8865-8873. doi: 10.1021/acsomega.8b01642. eCollection 2018 Aug 31.
2
Synthesis and self-sensitized photo-oxidation of 2-fulleropyrrolines by palladium(ii)-catalyzed heteroannulation of [60]fullerene with benzoyl hydrazone esters.钯(ii)催化[60]富勒烯与苯甲酰腙酯的杂环化反应合成 2-全富勒基吡咯啉及其自敏化光氧化。
Org Biomol Chem. 2018 Nov 21;16(45):8845-8853. doi: 10.1039/c8ob02417k.
3
Rhodium-Catalyzed Annulation of α-Imino Carbenes with α,β-Unsaturated Ketones: Construction of Multisubstituted 2,3-Dihydropyrrole/pyrrole Rings.
通过显微镜和光谱技术研究[Ni(Hvanox)]的薄膜生长。
Nanoscale Adv. 2025 Feb 12;7(7):2083-2091. doi: 10.1039/d4na01021c. eCollection 2025 Mar 25.
4
Enantioselective Borylcupration/Cyclization of Alkene-Tethered Oxime Esters.烯烃连接的肟酯的对映选择性硼氢化铜化/环化反应
Angew Chem Int Ed Engl. 2025 Mar 3;64(10):e202420479. doi: 10.1002/anie.202420479. Epub 2025 Feb 11.
5
Synthesis of Spiropyrrolines One-Pot TfO-Mediated Amide Activation/Formal [3 + 2]-Cycloaddition of α-Formylamino Ketones.螺吡咯啉的合成：三氟甲磺酸根介导的酰胺活化/α-甲酰氨基酮的形式[3+2]环加成一锅法
J Org Chem. 2024 Sep 20;89(18):13031-13037. doi: 10.1021/acs.joc.4c01128. Epub 2024 Sep 4.
6
Asymmetric Photoaerobic Lactonization and Aza-Wacker Cyclization of Alkenes Enabled by Ternary Selenium-Sulfur Multicatalysis.三元硒-硫多催化实现的烯烃不对称光氧内酯化和氮杂瓦克环化反应
ACS Catal. 2023 Dec 5;13(24):16240-16248. doi: 10.1021/acscatal.3c04443. eCollection 2023 Dec 15.
7
Tin(iv) chloride mediated (3 + 2) annulation of -2-aroyl-3-styrylcyclopropane-1,1-dicarboxylates with nitriles: diastereoselective access to 5-vinyl-1-pyrroline derivatives.四氯化锡介导的 -2-芳酰基-3-苯乙烯基环丙烷-1,1-二羧酸酯与腈的(3 + 2)环化反应：非对映选择性合成5-乙烯基-1-吡咯啉衍生物
RSC Adv. 2021 Apr 21;11(25):14980-14985. doi: 10.1039/d1ra01194d.
8
Synthesis and Toxicity Evaluation of New Pyrroles Obtained by the Reaction of Activated Alkynes with 1-Methyl-3-(cyanomethyl)benzimidazolium Bromide.新型吡咯的合成及其毒性评价，该吡咯由活性炔与 1-甲基-3-(氰甲基)苯并咪唑溴反应得到。
Molecules. 2021 Oct 25;26(21):6435. doi: 10.3390/molecules26216435.
铑催化的α-亚氨基卡宾与α,β-不饱和酮的环化反应：多取代 2,3-二氢吡咯/吡咯环的构建。
J Org Chem. 2018 Dec 7;83(23):14518-14526. doi: 10.1021/acs.joc.8b01835. Epub 2018 Nov 16.
4
3-Aryl-2,5-Dihydropyrroles via Catalytic Carbonyl-Olefin Metathesis.通过催化羰基-烯烃复分解反应合成3-芳基-2,5-二氢吡咯
ACS Catal. 2018 Mar 2;8(3):2006-2011. doi: 10.1021/acscatal.7b03769. Epub 2018 Jan 18.
5
Synthesis of 3-(Arylsulfonyl)-3-pyrrolines from Allenyl Sulfonamides by Silver Ion Catalysis.银离子催化烯基砜基磺酰胺合成 3-(芳基磺酰基)-3-吡咯啉。
Org Lett. 2018 Sep 21;20(18):5723-5726. doi: 10.1021/acs.orglett.8b02440. Epub 2018 Sep 4.
6
Catalytic Asymmetric [3 + 2] Cycloaddition Reaction between Aurones and Isocyanoacetates: Access to Spiropyrrolines via Silver Catalysis.金酮与异氰基乙酸酯之间的催化不对称[3+2]环加成反应：通过银催化合成螺吡咯啉
J Org Chem. 2018 Sep 21;83(18):10995-11007. doi: 10.1021/acs.joc.8b01622. Epub 2018 Jul 23.
7
A Novel Sc(OTf) -Catalyzed (2+2+1)-Cycloannulation/Aza-Friedel-Crafts Alkylation Sequence toward Multicyclic 2-Pyrrolines.一种新型 Sc(OTf) 催化的（2+2+1）-环加成/氮杂-Friedel-Crafts 烷基化序列合成多环 2-吡咯啉。
Chemistry. 2018 Sep 20;24(53):14207-14212. doi: 10.1002/chem.201802478. Epub 2018 Aug 22.
8
Regioselective Synthesis of Acylated N-Heterocycles via the Cascade Reactions of Saturated Cyclic Amines with 2-Oxo-2-arylacetic Acids.通过饱和环胺与2-氧代-2-芳基乙酸的串联反应区域选择性合成酰化氮杂环化合物。
J Org Chem. 2018 Jun 15;83(12):6524-6533. doi: 10.1021/acs.joc.8b00805. Epub 2018 May 24.
9
Direct Asymmetric Formal [3 + 2] Cycloaddition Reaction of Isocyanoesters with β-Trifluoromethyl β,β-Disubstituted Enones Leading to Optically Active Dihydropyrroles.手性异氰酸酯与β-三氟甲基β,β-二取代烯酮的直接不对称[3 + 2]环加成反应生成手性二氢吡咯。
Org Lett. 2018 May 4;20(9):2716-2719. doi: 10.1021/acs.orglett.8b00925. Epub 2018 Apr 23.
10
Copper-Catalyzed Domino Cyclization/Trifluoromethylthiolation of Unactivated Alkenes: Access to SCF-Containing Pyrrolines.铜催化的非活化烯烃的多米诺环化/三氟甲硫基化：含 SCF 的吡咯啉的获得。
Org Lett. 2018 Apr 20;20(8):2261-2264. doi: 10.1021/acs.orglett.8b00614. Epub 2018 Mar 27.