NHC 催化的氧化环化反应在 3-取代邻苯二甲酸酐合成中的应用。
NHC-catalyzed oxidative cyclization reaction for the synthesis of 3-substituted phthalides.
机构信息
Department of Chemistry and Research Institute for Natural Sciences, Hanyang University, Seoul 133-791, Korea.
出版信息
Org Biomol Chem. 2014 Apr 21;12(15):2388-93. doi: 10.1039/c3ob42546k.
PMID:24595463
Abstract
An efficient NHC-catalyzed domino oxidation/oxa-Michael addition reaction of 2-alkenylbenzaldehydes has been developed to afford 3-substituted phthalides bearing a C3-stereogenic center with a broad substrate scope and wide functional group tolerance. The preliminary results of the asymmetric process have been provided as well.
摘要
一种高效的 NHC 催化的 2-烯基苯甲醛的串联氧化/氧杂-Michael 加成反应已经被开发出来，用于提供具有 C3 手性中心的 3-取代的邻苯二甲酸内酯，具有广泛的底物范围和广泛的官能团容忍度。不对称过程的初步结果也已经提供。
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