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[德国良性甲状腺肿的手术治疗:手术例数减少、切除策略改变、并发症减少]

[Surgery for benign goiter in Germany: fewer operations, changed resectional strategy, fewer complications].

作者信息

Dralle H, Stang A, Sekulla C, Rusner C, Lorenz K, Machens A

机构信息

Universitätsklinik für Allgemein-, Viszeral- und Gefäßchirurgie, Universitätsklinikum Halle, Medizinische Fakultät der Martin-Luther-Universität Halle-Wittenberg, Ernst-Grube-Str. 40, 06120, Halle (Saale), Deutschland,

出版信息

Chirurg. 2014 Mar;85(3):236-45. doi: 10.1007/s00104-013-2705-7.

Abstract

BACKGROUND

The increase of certain operations in the wake of the introduction of the German Diagnosis-Related Groups (G-DRG) system rekindled debate on the risk-benefit profile of what is widely being perceived as a too high number of thyroidectomies for benign goiter in Germany.

MATERIAL AND METHODS

The numbers of thyroidectomy for benign goiter from 2005-2011 were obtained from the Federal Bureau of Statistics ("Statistisches Bundesamt"). For the purpose of the study, the following operation and procedure key (OPS) codes were selected: hemithyroidectomy (OPS code 5-061); partial thyroid resection (OPS code 5-062); total thyroidectomy (OPS code 5-063); and thyroid surgeries via sternotomy (OPS code 5-064). The rates of permanent hypoparathyroidism and vocal cord palsy were calculated based on two prospective multicenter evaluation studies conducted in 1998-2001 (PETS 1) and 2010-2013 (PETS 2) in Germany.

RESULTS

Between 2005 and 2011, the number of thyroidectomies for benign thyroid goiter decreased by 8 %, and the age-standardized surgery rate decreased by 6 % in men (2005: 599 per 1 million; 2011: 565 per 1 million) and 11 % in women (2005: 1641 per 1 million; 2011: 1463 per 1 million). At the same time, the rates of partial and subtotal thyroidectomy decreased by 59 % in men and 64 % in women, whereas the rates of hemithyroidectomy and total thyroidectomy increased by 65 % (113 %) in men and 42 % (97 %) in women. Despite a greater proportion of thyroidectomies over time, the approximated rates for postoperative hypoparathyroidism were reduced from 2.98 to 0.83 % and for postoperative vocal cord palsy from 1.06 to 0.86 %. Irrespective of that decline, either complication was more frequent after total than after subtotal thyroidectomy.

CONCLUSION

The total number of thyroid surgeries due to benign goiter has decreased substantially in Germany from 2005 through 2011. Despite changes in the resectional strategy with an increase in the total number thyroidectomies and a decrease of subtotal resections, the rates for postoperative hypoparathyroidism and vocal cord palsy have decreased. The complication rates for total thyroidectomy, however, are still higher compared to subtotal resection. An individualized risk-oriented surgical approach is warranted.

摘要

背景

德国诊断相关分组(G-DRG)系统引入后,某些手术数量的增加再次引发了关于德国良性甲状腺肿甲状腺切除术数量过多这一普遍认知的风险效益概况的争论。

材料与方法

2005 - 2011年良性甲状腺肿甲状腺切除术的数量来自联邦统计局(“德国联邦统计局”)。为进行本研究,选取了以下手术及操作编码(OPS):半甲状腺切除术(OPS编码5 - 061);部分甲状腺切除术(OPS编码5 - 062);全甲状腺切除术(OPS编码5 - 063);以及经胸骨切开术的甲状腺手术(OPS编码5 - 064)。永久性甲状旁腺功能减退和声带麻痹的发生率是根据1998 - 2001年(PETS 1)和2010 - 2013年(PETS 2)在德国进行的两项前瞻性多中心评估研究计算得出的。

结果

2005年至2011年期间,良性甲状腺肿甲状腺切除术的数量减少了8%,年龄标准化手术率在男性中下降了6%(2005年:每100万人中有599例;2011年:每100万人中有565例),在女性中下降了11%(2005年:每100万人中有1641例;2011年:每100万人中有1463例)。与此同时,部分和次全甲状腺切除术的发生率在男性中下降了59%,在女性中下降了64%,而半甲状腺切除术和全甲状腺切除术的发生率在男性中增加了65%(113%),在女性中增加了42%(97%)。尽管随着时间推移甲状腺切除术的比例有所增加,但术后甲状旁腺功能减退的估计发生率从2.98%降至0.83%,术后声带麻痹的发生率从1.06%降至0.86%。尽管有这种下降,但无论哪种并发症,全甲状腺切除术后都比次全甲状腺切除术后更常见。

结论

2005年至2011年期间,德国因良性甲状腺肿进行的甲状腺手术总数大幅下降。尽管切除策略发生了变化,全甲状腺切除术数量增加,次全切除术数量减少,但术后甲状旁腺功能减退和声带麻痹的发生率有所下降。然而,全甲状腺切除术的并发症发生率仍高于次全切除术。需要一种个体化的、以风险为导向的手术方法。

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