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良性甲状腺肿手术的当前实践——对前瞻性德国甲状腺、甲状旁腺和肾上腺外科学会(DGAV)StuDoQ|甲状腺登记处的分析

Current Practice of Surgery for Benign Goitre-An Analysis of the Prospective DGAV StuDoQ|Thyroid Registry.

作者信息

Bartsch Detlef K, Dotzenrath Cornelia, Vorländer Christian, Zielke Andreas, Weber Theresia, Buhr Heinz J, Klinger Carsten, Lorenz Kerstin, The StuDoQ/Thyroid Study Group The StuDoQ/Thyroid Study

机构信息

Department of Visceral-, Thoracic- and Vascular Surgery, Philipps-University Marburg, 35043 Marburg, Germany.

Department of Endocrine Surgery, Helios University Hospital Wuppertal, 42283 Wuppertal, Germany.

出版信息

J Clin Med. 2019 Apr 8;8(4):477. doi: 10.3390/jcm8040477.

Abstract

BACKGROUND

To evaluate the current indications, resection strategies and short-term outcomes of surgery for benign goitre in a country with endemic goitre.

METHODS

Data of patients who underwent surgery for benign goitre were retrieved from the prospective StuDoQ/Thyroid registry and retrospectively analysed regarding the patient's demographics, indications for surgery, surgical procedures, histology, and perioperative outcomes.

RESULTS

In a 15-month period, 12,888 patients from 83 departments underwent thyroid resections for benign conditions. Main indications for surgery were exclusion of malignancy (68%), compression symptoms (20.7%) and hyperthyroidism (9.7%). Preoperative fine needle aspiration cytology was performed in only 12.2% of patients with the indication "exclusion of malignancy". Thyroidectomy (49.8%) or hemithyroidectomy (36.9%) were performed in 86.7% of patients. Minimally invasive or alternative surgical techniques were applied in only 2.2%. Intraoperative neuromonitoring was used in 98.4% of procedures, in 97.5% of patients at least one parathyroid gland was visualized, and in 15.3% of patients parathyroid tissue was autografted, respectively. The rates of unilateral and bilateral transient recurrent nerve palsy were 3.6% and 0.07% of nerves at risk, the rate of transitory hypoparathyroidism was 15.3%. The rates of postoperative bleeding and wound infections requiring reoperation were 1.4% and 0.07%, respectively.

CONCLUSIONS

The indication "exclusion of malignancy" is made too liberally, and there is a strong attitude to perform complete thyroid resections. Postoperative hypoparathyroidism is the major complication after surgery for benign thyroid disease, thus requiring more awareness.

摘要

背景

在一个地方性甲状腺肿流行的国家,评估当前良性甲状腺肿手术的适应证、切除策略和短期结果。

方法

从前瞻性的StuDoQ/甲状腺登记处检索接受良性甲状腺肿手术患者的数据,并对患者的人口统计学、手术适应证、手术方式、组织学和围手术期结果进行回顾性分析。

结果

在15个月的时间里,来自83个科室的12888例患者因良性疾病接受了甲状腺切除术。手术的主要适应证是排除恶性肿瘤(68%)、压迫症状(20.7%)和甲状腺功能亢进(9.7%)。仅12.2%有“排除恶性肿瘤”适应证的患者进行了术前细针穿刺细胞学检查。86.7%的患者接受了甲状腺切除术(49.8%)或甲状腺半切除术(36.9%)。仅2.2%的患者应用了微创或替代手术技术。98.4%的手术使用了术中神经监测,97.5%的患者至少可见一个甲状旁腺,15.3%的患者进行了甲状旁腺组织自体移植。单侧和双侧暂时性喉返神经麻痹的发生率分别为有风险神经的3.6%和0.07%,暂时性甲状旁腺功能减退的发生率为15.3%。术后出血和需要再次手术的伤口感染发生率分别为1.4%和0.07%。

结论

“排除恶性肿瘤”的适应证把握过于宽松,且存在强烈的进行甲状腺全切术的倾向。术后甲状旁腺功能减退是良性甲状腺疾病手术后的主要并发症,因此需要更多关注。

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