Shobhit Shobhit, Gupta Satish Kumar
Department of Pharmaceutical Technology, Meerut Institute of Engineering and Technology, Meerut, India.
Polim Med. 2013 Oct-Dec;43(4):227-9.
In the present study, Mouth Dissolving Tablets (MDTs) of aceclofenac were formulated by direct compression technique. Sodium starch glycolate and crospovidone were employed as superdisintegrants in various concentrations like 2%, 3% and 4% w/w. All prepared tablets were evaluated for weight variation, hardness, drug content, friability, disintegration time, in vitro wetting time and percent drug release. MDTs containing 4% w/w concentration of crospovidone give best results and is therefore considered as the best formula. It has shown 30 s disintegration time, 25 s wetting time and 79.34% in vitro release of drug in 25 min.
在本研究中，采用直接压片技术制备了醋氯芬酸口腔崩解片。以不同浓度（2%、3%和4% w/w）的羟丙基淀粉和交联聚维酮作为超级崩解剂。对所有制备的片剂进行了重量差异、硬度、药物含量、脆碎度、崩解时间、体外润湿时间和药物释放百分比的评估。含4% w/w交联聚维酮浓度的口腔崩解片效果最佳，因此被认为是最佳配方。其崩解时间为30秒，润湿时间为25秒，在25分钟内药物的体外释放率为79.34%。
