Patra S, Sahoo R, Panda R K, Himasankar K, Barik B B
University Department of Pharmaceutical Sciences, Utkal University, Vani Vihar, Bhubaneswar - 751 004, India.
Indian J Pharm Sci. 2010 Nov;72(6):822-5. doi: 10.4103/0250-474X.84607.
In the present research work mouth dissolving tablets of domperidone were developed with superdisintegrants like crospovidone, croscarmellose sodium and sodium starch glycollate in various concentrations like 3%, 4% and 6% w/w by direct compression method. All formulations were evaluated for physical characteristics of compressed tablets such as weight variation, hardness, friability, content uniformity, in vitro disintegration time, wetting time and in vitro dissolution study. Among all, the formulation F3 (containing 6% w/w concentration of crospovidone) was considered to be the best formulation, having disintegration time of 9 s, wetting time of 15 s and in vitro drug release of 99.22% in 15 min.
在本研究工作中，采用直接压片法，使用交联聚维酮、交联羧甲基纤维素钠和羟丙基淀粉等超级崩解剂，以3%、4%和6%（w/w）的不同浓度制备了多潘立酮口腔崩解片。对所有制剂的压制片进行了物理特性评估，如重量差异、硬度、脆碎度、含量均匀度、体外崩解时间、润湿时间和体外溶出度研究。其中，制剂F3（含6%（w/w）浓度的交联聚维酮）被认为是最佳制剂，崩解时间为9秒，润湿时间为15秒，15分钟内的体外药物释放率为99.22%。
