Memorial Sloan-Kettering Cancer Center, New York, New York.
Cancer Discov. 2014 Mar;4(3):273-4. doi: 10.1158/2159-8290.CD-14-0069.
In this issue of Cancer Discovery, Romero and colleagues identify somatic mutations and deletions of MAX, and also define what seem to be mutually exclusive alterations in MYC family members and other MYC-associated factors in small cell lung cancer. Taken together, these data highlight the importance of MYC signaling in small cell lung cancer and suggest possible avenues for therapeutic intervention.
在本期《Cancer Discovery》中，Romero 及其同事鉴定了小细胞肺癌中 MAX 的体细胞突变和缺失，并定义了似乎相互排斥的 MYC 家族成员和其他与 MYC 相关因子的改变。这些数据共同强调了 MYC 信号在小细胞肺癌中的重要性，并提示了可能的治疗干预途径。
