长期脐血造血干细胞移植后长期成人幸存者中 HHV-6 的持续再激活。
Long-lasting HHV-6 reactivation in long-term adult survivors after double umbilical cord blood allogeneic stem cell transplantation.
机构信息
Centre Hospitalier et Universitaire (CHU) de Nantes, Département de Virologie, Nantes France and EA4271 «Immunovirology and Genetic Polymorphism», University of Nantes.
Centre Hospitalier et Universitaire (CHU) de Nantes, Hématologie Clinique, Centre d'Investigation Clinique en Cancérologie (CI2C), Nantes.
出版信息
J Infect Dis. 2014 Aug 15;210(4):567-70. doi: 10.1093/infdis/jiu129. Epub 2014 Mar 4.
Higher incidence of human herpesvirus 6 (HHV-6) infection has been documented after umbilical cord blood allo-transplant in adults. Here we demonstrate that HHV-6 reactivation persists for a very long time in half of the patients after this type of graft. Long-term immune reconstitution does not explain this event, which remains to be explained.
有研究报道，成人脐带血异体移植后人类疱疹病毒 6（HHV-6）感染的发生率较高。在此我们证明，在这种类型的移植物后，有一半患者的 HHV-6 持续长时间再激活。长期免疫重建并不能解释这一事件，其原因仍有待阐明。
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