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脂类浓度与精液质量:LIFE 研究。

Lipid concentrations and semen quality: the LIFE study.

机构信息

Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Rockville, MD, USA.

出版信息

Andrology. 2014 May;2(3):408-15. doi: 10.1111/j.2047-2927.2014.00198.x. Epub 2014 Mar 5.

Abstract

The decline in sperm count rates over the last 50 years appears to parallel the rising prevalence of obesity. As lipid levels are strongly associated with obesity, high lipids levels or hyperlipidaemia may thus play an important role in the decline in fertility in addition to other environmental or lifestyle factors. The objective of this population based cohort study was to evaluate the association between men's serum lipid concentrations and semen quality parameters among 501 male partners of couples desiring pregnancy and discontinuing contraception. Each participant provided prospectively up to two semen samples (94% of men provided one or more semen samples, and 77% of men provided a second sample approximately 1 month later). Linear mixed effects models were used to estimate the associations between baseline lipid concentrations and semen quality parameters, adjusted for age, body mass index and race. We found that higher levels of serum total cholesterol, free cholesterol and phospholipids were associated with a significantly lower percentage of spermatozoa with intact acrosome and smaller sperm head area and perimeter. Our results suggest that lipid concentrations may affect semen parameters, specifically sperm head morphology, highlighting the importance of cholesterol and lipid homeostasis for male fecundity.

摘要

在过去的 50 年中,精子数量的下降似乎与肥胖症的发病率上升呈平行关系。由于脂质水平与肥胖密切相关,因此高水平的脂质或高脂血症可能除了其他环境或生活方式因素外,在生育能力下降中发挥重要作用。本项基于人群的队列研究的目的是评估在 501 名希望怀孕并停止避孕的夫妇的男性伴侣中,血清脂质浓度与精液质量参数之间的关系。每位参与者前瞻性地提供了多达两份精液样本(94%的男性提供了一份或多份精液样本,而 77%的男性大约一个月后提供了第二份样本)。使用线性混合效应模型来估计基线脂质浓度与精液质量参数之间的关联,调整了年龄,体重指数和种族。我们发现,血清总胆固醇,游离胆固醇和磷脂水平较高与顶体完整的精子百分比,较小的精子头部面积和周长明显降低有关。我们的结果表明,脂质浓度可能会影响精液参数,特别是精子头部形态,突出了胆固醇和脂质动态平衡对男性生育能力的重要性。

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