The Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, 310053, China.
Department of Reproductive Medicine, Zhejiang Provincial Integrated Chinese and Western Medicine Hospital, 208 East HuanCheng Road, Hangzhou, 310003, China.
Reprod Biol Endocrinol. 2020 Sep 29;18(1):95. doi: 10.1186/s12958-020-00652-6.
The current evidence on the association between obesity-associated markers and semen quality, serum reproductive hormones and lipids remains inconsistent. In this study, we tested the hypothesis that, in infertile Chinese men, body mass index (BMI) negatively correlates with sperm concentration, serum total testosterone (TT), and high-density lipoprotein cholesterol (HDL-C). The relationship between other obesity-associated markers and semen quality parameters, serum reproductive hormones, lipids and leptin were also investigated.
181 Chinese infertile men were recruited from September 2018 to September 2019. Their obesity-associated markers, semen parameters, and serum reproductive hormones, lipids and leptin were detected. Statistical analysis was performed to assess the relationship between obesity-associated markers and semen quality, serum reproductive hormones, lipids and leptin.
RESULT(S): Statistically negative correlation was found between other obesity-associated markers (e.g. waist-to-hip ratio and waist-to-height ratio) and semen parameters (e.g. sperm concentration, ratio of progressive motility and ratio of non-progressive motility), while no significant correlation was found between BMI and semen quality, serum reproductive hormones, lipids and leptin. Ratio of morphologically normal sperm was negatively correlated with serum lipids including total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C), leptin and seminal superoxide dismutase. Ratio of progressive sperm, sperm concentration and ratio of morphologically normal sperm exhibited significantly lower values in overweight group than normal group. Estradiol (E2) and E2/TT were significantly higher in obese group than normal group, while TT level was significantly lower in obese group than normal group. Univariate and multivariate analysis indicated that TC was significantly associated with BMI. Serum leptin concentration was positively correlated with seminal leptin concentration in overweight and obese groups.
CONCLUSION(S): No significant correlation was found between BMI and sperm concentration, serum TT and HDL-C, while other obesity-associated markers were found to negatively correlate with sperm concentration, ratio of progressive motility and ratio of non-progressive motility. Statistically significant correlations between serum reproductive hormones, lipids and leptin also existed in Chinese infertile men.
肥胖相关标志物与精液质量、血清生殖激素和血脂之间的关联，目前的证据仍不一致。在这项研究中，我们检验了这样一个假设，即肥胖相关标志物与精液浓度、血清总睾酮（TT）和高密度脂蛋白胆固醇（HDL-C）呈负相关。还研究了其他肥胖相关标志物与精液质量参数、血清生殖激素、血脂和瘦素之间的关系。
从 2018 年 9 月至 2019 年 9 月，招募了 181 名中国不育男性。检测了他们的肥胖相关标志物、精液参数、血清生殖激素、血脂和瘦素。进行了统计分析，以评估肥胖相关标志物与精液质量、血清生殖激素、血脂和瘦素之间的关系。
其他肥胖相关标志物（如腰臀比和腰高比）与精液参数（如精子浓度、前向运动精子比例和非前向运动精子比例）呈统计学负相关，而 BMI 与精液质量、血清生殖激素、血脂和瘦素无显著相关性。形态正常精子比例与血清总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、瘦素和精液超氧化物歧化酶等脂质呈负相关。超重组的前向运动精子比例、精子浓度和形态正常精子比例明显低于正常组。肥胖组的雌二醇（E2）和 E2/TT 明显高于正常组，而 TT 水平明显低于正常组。单因素和多因素分析表明，TC 与 BMI 显著相关。超重和肥胖组血清瘦素浓度与精液瘦素浓度呈正相关。
BMI 与精子浓度、血清 TT 和 HDL-C 无显著相关性，而其他肥胖相关标志物与精子浓度、前向运动精子比例和非前向运动精子比例呈负相关。中国不育男性的血清生殖激素、血脂和瘦素之间也存在显著的相关性。
