Esposito F, Lombardi S, Modiano D, Zavala F, Reeme J, Lamizana L, Coluzzi M, Nussenzweig R S
Dipartimento di Biologia Cellulare, Università di Camerino, Italy.
Parassitologia. 1986 Aug-Dec;28(2-3):101-5.
The presence of antibodies against Plasmodium falciparum sporozoites in humans living in malaria endemic areas was measured using as antigen the synthetic peptide (NANP)3, which represents the immunodominant region of the circumsporozoite (CS) protein. The results indicate that: i) the production of anti-CS antibodies is unrelated to the presence in the circulation of blood-stage parasites; ii) anti-CS antibodies, raised by natural inoculation, could exert a protective role against natural malaria infection; iii) anti-CS antibodies can be used as indicators of the intensity of malaria transmission.
采用合成肽（NANP）3作为抗原，测定生活在疟疾流行地区的人群中抗恶性疟原虫子孢子抗体的存在情况，该合成肽代表环子孢子蛋白（CS）的免疫显性区域。结果表明：i）抗CS抗体的产生与血液期寄生虫在循环系统中的存在无关；ii）通过自然接种产生的抗CS抗体可对自然疟疾感染发挥保护作用；iii）抗CS抗体可作为疟疾传播强度的指标。
