Kumar Sathish Selva, Ramachandran Padmini, G Veena, Madhusudhan Napa, Kumbhar Uday
Assistant Professor, Department of Pathology, ESI Medical College and Post Graduate Institute of Medical Science and Research (PGIMSR) , Tamil Nadu, India .
Senior Resident, Department of Pathology, ESI Medical College and Post Graduate Institute of Medical Science and Research (PGIMSR) , Tamil Nadu, India .
J Clin Diagn Res. 2014 Jan;8(1):168-9. doi: 10.7860/JCDR/2014/7358.3901. Epub 2013 Sep 30.
Desmoid Tumour (DT) is a rare benign, myofibroblastic tumour originating from muscle fascia with tendency to recur but, it rarely metastasizes. We are reporting here a case of DT that presented as an intra-abdominal mass with pelvic extension in a patient who underwent hysterectomy for fibroid uterus seventeen years ago. A clinical diagnosis of ovarian malignancy was made. Ovarian tumour markers for surface epithelial and germ cell tumours were negative. Imaging studies suggested DT and the same was excised surgically. A histopathological diagnosis of DT was made and confirmed with immunohistochemistry (IHC) markers. DT should always be considered especially in female patients with previous history of surgery. A complete surgical excision is the treatment of choice with recurrent cases requiring radiotherapy. A differential diagnosis like sarcoma and further toxic chemotherapy can be avoided with careful histopathological evaluation and IHC confirmation of DTs.
硬纤维瘤（DT）是一种罕见的良性肌成纤维细胞瘤，起源于肌筋膜，有复发倾向，但很少发生转移。我们在此报告一例硬纤维瘤病例，该病例表现为腹腔内肿块并向盆腔扩展，患者17年前因子宫肌瘤接受了子宫切除术。临床诊断为卵巢恶性肿瘤。表面上皮和生殖细胞肿瘤的卵巢肿瘤标志物均为阴性。影像学检查提示为硬纤维瘤，并通过手术切除。经组织病理学诊断为硬纤维瘤，并通过免疫组织化学（IHC）标志物得以证实。尤其是有手术史的女性患者，应始终考虑到硬纤维瘤的可能。完整的手术切除是首选治疗方法，复发病例需要放疗。通过仔细的组织病理学评估和硬纤维瘤的免疫组织化学确认，可以避免肉瘤等鉴别诊断以及进一步的毒性化疗。
