Graduate School of Pharmaceutical Sciences, Tohoku University, Japan.
J Pharmacol Sci. 2014;124(3):301-6. doi: 10.1254/jphs.13r16cp. Epub 2014 Mar 4.
Environmental chemicals, such as cigarette smoke and diesel exhaust, have been reported as risk factors that exacerbate allergic diseases. However, the exacerbation mechanisms induced by these chemicals are not yet fully understood. Thymic stromal lymphopoietin (TSLP) is produced mainly by epithelial cells and plays an important role as a master switch of allergic inflammation because it promotes Th2-type immune responses by inducing the activation of dendritic cells. Chemical compounds, such as formalin, have been shown to bind to proteins and form a new antigen that induces allergic responses. A second group of chemicals that enhance allergic responses to exogenous proteins have also been reported. We recently demonstrated that some of these chemicals induced TSLP production and may potentially augment Th2-type allergic responses. We proposed that TSLP-producing chemical compounds should be recognized as chemical allegro-accelerators.
环境化学物质，如香烟烟雾和柴油废气，已被报道为加重过敏疾病的危险因素。然而，这些化学物质引起的恶化机制尚不完全清楚。胸腺基质淋巴细胞生成素 (TSLP) 主要由上皮细胞产生，作为过敏炎症的主开关发挥重要作用，因为它通过诱导树突状细胞的激活来促进 Th2 型免疫反应。已经表明，某些化学化合物，如甲醛，与蛋白质结合形成新的抗原，从而诱导过敏反应。也有报道称，有第二组化学物质增强对外源蛋白质的过敏反应。我们最近证明，其中一些化学物质诱导 TSLP 的产生，并且可能潜在地增强 Th2 型过敏反应。我们提出，产生 TSLP 的化学化合物应被视为化学促发剂。
