Molecular Pharmacology, Department of Biofunctional Evaluation, Gifu Pharmaceutical University, Japan.
J Pharmacol Sci. 2014;124(3):336-43. doi: 10.1254/jphs.13r07cr. Epub 2014 Mar 4.
Diacylglycerol kinase (DGK) is an enzyme that converts diacylglycerol to phosphatidic acid. To date, 10 isoforms of DGKs (α, β, γ, δ, ε, ζ, η, θ, ι, and κ) have been identified in mammals, and these DGKs show characteristic expression patterns and roles. The expression levels of DGKs are comparatively higher in the central nervous system than in other organs and may play several important roles in regulating higher brain functions. Currently, many studies have been performed to reveal the roles of DGKs by knocking down or overexpression of DGKs in vitro. Additionally, knockout or overexpression mice of several DGKs have been generated, and phenotypes of these mice have been studied. In this review, we discuss the roles of DGKs in the central nervous system based on recent findings in genetic models.
二酰基甘油激酶 (DGK) 是一种将二酰基甘油转化为磷脂酸的酶。迄今为止，已在哺乳动物中鉴定出 10 种 DGK 同工型（α、β、γ、δ、ε、ζ、η、θ、ι 和 κ），这些 DGK 表现出特征性的表达模式和作用。DGK 的表达水平在中枢神经系统中比在其他器官中相对较高，可能在调节大脑高级功能方面发挥几个重要作用。目前，许多研究通过在体外敲低或过表达 DGK 来揭示 DGK 的作用。此外，还生成了几种 DGK 的敲除或过表达小鼠，并研究了这些小鼠的表型。在这篇综述中，我们根据遗传模型中的最新发现讨论了 DGK 在中枢神经系统中的作用。
