未活化仲烷基卤化物的交叉偶联：室温下镍催化的溴代烷和碘代烷的根岸反应
Cross-couplings of unactivated secondary alkyl halides: room-temperature nickel-catalyzed Negishi reactions of alkyl bromides and iodides.
作者信息
Zhou Jianrong Steve, Fu Gregory C
机构信息
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
出版信息
J Am Chem Soc. 2003 Dec 3;125(48):14726-7. doi: 10.1021/ja0389366.
PMID:14640646
Abstract
The development of a nickel- or palladium-catalyzed method for cross-coupling unactivated secondary alkyl halides has been a long-standing challenge in synthetic chemistry. This communication describes a simple catalyst system-Ni(cod)2/s-Bu-Pybox-that achieves room-temperature Negishi reactions of an array of functionalized primary and secondary alkyl bromides and iodides.
摘要
开发一种用于未活化仲卤代烃交叉偶联的镍或钯催化方法一直是合成化学中长期存在的挑战。本通讯描述了一种简单的催化剂体系——Ni(cod)2/s-Bu-Pybox，它能实现一系列功能化伯卤代烃和仲卤代烃在室温下的根岸反应。
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