趋化因子受体5 Δ32多态性与系统性红斑狼疮、血管炎及原发性干燥综合征：可能关联的荟萃分析
Chemokine receptor 5 Δ32 polymorphism and systemic lupus erythematosus, vasculitis, and primary Sjogren's syndrome. Meta-analysis of possible associations.
作者信息
Lee Y H, Kim J-H, Song G G
机构信息
Division of Rheumatology, Department of Internal Medicine, Korea University Anam Hospital, Korea University College of Medicine, 126-1, Anam-dong 5-ga, Seongbuk-gu , 136-705, Seoul, Korea,
出版信息
Z Rheumatol. 2014 Nov;73(9):848-55. doi: 10.1007/s00393-014-1356-5.
OBJECTIVE
The aim of this study was to determine whether the functional chemokine receptor 5 delta32 (CCR5-Δ32) polymorphism is associated with susceptibility to systemic lupus erythematosus (SLE), vasculitis, and primary Sjogren's syndrome (pSS).
RESULTS
A total of 12 studies were analyzed, including 5 on SLE, 5 on vasculitis, and 2 on pSS, encompassing 1881 patients and 2391 controls. Meta-analysis indicated no association between SLE and the CCR5-Δ32 allele (OR 0.842, 95 % CI 0.793-1.804, p = 0.657), and no association between the CCR5-Δ32 allele and SLE in Europeans (OR 0.647, 95 % CI 0.306-1.368, p = 0.255). Meta-analysis of the CCR5-Δ32 allele and the Δ32Δ32 + Δ32 W genotype showed no association with lupus nephritis (LN; OR 1.771, 95 % CI 0.475-6.595, p = 0.395; OR 2.192, 95 % CI 0.182-26.42, p = 0.537, respectively). In addition, meta-analysis revealed no association between the CCR5-Δ32 allele and vasculitis in all study subjects and in Europeans (OR 1.241, 95 % CI 0.951-1.620, p = 0.111; OR 1.359, 95 % CI 0.803-2.303, p = 0.254, respectively). However, the overall OR for the CCR5-Δ32 allele was significantly higher in Kawasaki disease (KD; OR 1.746, 95 % CI 1.003-2.955, p = 0.038) and the meta-analysis of the Δ32Δ32 + Δ32 W genotype showed a trend indicating an association with KD (OR 1.683, 95 % CI 0.921-3.077, p = 0.091). No association was found between the CCR5-Δ32 polymorphism and pSS.
CONCLUSION
This meta-analysis demonstrates that the CCR5-Δ32 polymorphism is associated with KD, but does not facilitate susceptibility to SLE, LN, or pSS.
目的
本研究旨在确定功能性趋化因子受体5 delta32（CCR5-Δ32）多态性是否与系统性红斑狼疮（SLE）、血管炎及原发性干燥综合征（pSS）的易感性相关。
结果
共分析了12项研究，其中5项关于SLE，5项关于血管炎，2项关于pSS，涵盖1881例患者和2391例对照。荟萃分析表明，SLE与CCR5-Δ32等位基因之间无关联（比值比[OR]0.842，95%置信区间[CI]0.793 - 1.804，p = 0.657），在欧洲人中CCR5-Δ32等位基因与SLE也无关联（OR 0.647，95% CI 0.306 - 1.368，p = 0.255）。对CCR5-Δ32等位基因和Δ32Δ32 + Δ32W基因型的荟萃分析显示，其与狼疮性肾炎（LN）无关联（分别为OR 1.771，95% CI 0.475 - 6.595，p = 0.395；OR 2.192，95% CI 0.182 - 26.42，p = 0.537）。此外，荟萃分析显示，在所有研究对象及欧洲人中，CCR5-Δ32等位基因与血管炎均无关联（分别为OR 1.241，95% CI 0.951 - 1.620，p = 0.111；OR 1.359，95% CI 0.803 - 2.303，p = 0.254）。然而川崎病（KD）中CCR5-Δ32等位基因的总体OR显著更高（OR 1.746，95% CI 1.003 - 2.955，p = 0.038），对Δ32Δ32 + Δ32W基因型的荟萃分析显示有与KD相关的趋势（OR 1.683，95% CI 0.921 - 3.077，p = 0.091）。未发现CCR5-Δ32多态性与pSS之间存在关联。
结论
本荟萃分析表明，CCR5-Δ32多态性与KD相关，但与SLE、LN或pSS的易感性无关。
Zotero 插件