Lee Y H, Bae S-C, Kim J-H, Seo Y H, Choi S J, Ji J D, Song G G
Division of Rheumatology, Department of Internal Medicine, Korea University Anam Hospital, Korea University College of Medicine, 126-1, Anam-dong 5-ga, Seongbuk-gu, 136-705, Seoul, Korea,
Z Rheumatol. 2015 May;74(4):351-8. doi: 10.1007/s00393-014-1447-3.
The aim in this study was to determine whether solute carrier family 22, member 4 (SLC22A4), and runt-related transcription factor 1 (RUNX1) polymorphisms are associated with susceptibility to rheumatoid arthritis (RA) in populations of different ethnicities.
We conducted a literature search using the MEDLINE and EMBASE, and performed a meta-analysis using a fixed or random effects model.
A total of 26 comparative studies from 14 articles met the study inclusion criteria. Studies on the SLC22A4 polymorphism involved 12,458 RA patients and 9283 controls, and studies on the RUNX1 polymorphism involved 3958 RA patients and 3773 controls. The meta-analysis showed no association between the 22 + 21 genotype of the SLC22A4 F1 and RA in overall group [odds ratio (OR) 1.074, 95 % confidence interval (CI) 0.952-1.212, p = 0.245]. After stratification by ethnicity, the meta-analysis indicated that the 22 + 21 genotype of the SLC22A4 F1 was associated significantly with RA in the East Asian population, but not in the European population (OR 1.124, 95 % CI 1.018-1.240, p = 0.021; OR 0.981, 95 % CI 0.773-1.243, p = 0.871).
This meta-analysis demonstrates that the SLC22A4 F1 polymorphism is associated with susceptibility to RA in East Asians, but not in Europeans.
本研究旨在确定溶质载体家族22成员4（SLC22A4）和 runt相关转录因子1（RUNX1）基因多态性是否与不同种族人群类风湿关节炎（RA）的易感性相关。
我们使用MEDLINE和EMBASE进行文献检索，并采用固定或随机效应模型进行荟萃分析。
14篇文章中的26项比较研究符合纳入标准。SLC22A4基因多态性研究涉及12458例RA患者和9283例对照，RUNX1基因多态性研究涉及3958例RA患者和3773例对照。荟萃分析显示，总体组中SLC22A4 F1的22 + 21基因型与RA无关联[比值比（OR）1.074，95%置信区间（CI）0.952 - 1.212，p = 0.245]。按种族分层后，荟萃分析表明，SLC22A4 F1的22 + 21基因型在东亚人群中与RA显著相关，但在欧洲人群中无相关性（OR 1.124，95% CI 1.018 - 1.240，p = 0.021；OR 0.981，95% CI 0.773 - 1.243，p = 0.871）。
这项荟萃分析表明，SLC22A4 F1基因多态性与东亚人RA易感性相关，但与欧洲人无关。
