Colombatto S, Fasulo L, Grillo M A
Dipartimento di Medicina e Oncologia Sperimentale, Università di Torino, Italy.
Agents Actions. 1988 Jul;24(3-4):326-30. doi: 10.1007/BF02028290.
The effect of turpentine, a chemical inflammatory agent, on polyamine synthesis has been studied. Ornithine decarboxylase activity is markedly increased in liver 6 hrs after subcutaneous injection of turpentine, and then decreases. No significant modification is observed in S-adenosylmethionine decarboxylase. Putrescine injected prior to turpentine prevents this increase. Putrescine, spermidine and spermine concentrations are all increased following turpentine, but with different patterns: spermidine alone keeps increasing for 50 hours. Putrescine and spermidine injected prior to turpentine partially counteract the increase of serum alpha 2-macroglobulin, which is believed to be a marker of inflammation.
已经研究了化学炎症介质松节油对多胺合成的影响。皮下注射松节油6小时后，肝脏中的鸟氨酸脱羧酶活性显著增加，然后下降。S-腺苷甲硫氨酸脱羧酶未观察到明显变化。在注射松节油之前注射腐胺可防止这种增加。注射松节油后，腐胺、亚精胺和精胺的浓度均升高，但模式不同：仅亚精胺持续增加50小时。在注射松节油之前注射腐胺和亚精胺可部分抵消血清α2-巨球蛋白的增加，血清α2-巨球蛋白被认为是炎症的标志物。
