Simpson R J, Amara I, Foster J R, Woelfel A, Gettes L S
Department of Medicine, University of North Carolina, Chapel Hill 27599.
Am Heart J. 1988 Oct;116(4):1080-90. doi: 10.1016/0002-8703(88)90163-9.
In order to better understand the electrophysiology of the diseased human atrium, we measured high right atrial refractory periods, threshold, and conduction times of 61 patients undergoing routine electrophysiologic study. Refractory periods and conduction times of patients with apparently normal atria were compared to those of patients with a history of persistent sinus bradycardia, atrial fibrillation, or other forms of primary atrial tachyarrhythmia. Refractory periods and thresholds were derived from strength-interval curves. Conduction times were measured for all premature beats induced. Threshold, refractory periods, and conduction times of premature beats induced late in the cardiac cycle did not distinguish patients with normal atria from patients with bradycardia or tachycardia. In contrast, increases in conduction time of early cycle premature beats separated patients with these abnormalities from patients with normal atria. The increases in interatrial and intraatrial conduction time of early cycle premature beats were the strongest correlates of primary atrial tachyarrhythmia (r = 0.52, p = 0.0065 and r = 0.274, p = 0.041, respectively) and induction of repetitive atrial firing (r = 0.65, p = 0.002, and r = 0.59, p = 0.0001, respectively). This increase in conduction time of early cycle premature beats may predispose these patients to primary atrial tachyarrhythmias.
为了更好地了解患病人类心房的电生理学，我们测量了61例接受常规电生理研究患者的高位右心房不应期、阈值和传导时间。将心房外观正常患者的不应期和传导时间与有持续性窦性心动过缓、心房颤动或其他原发性房性快速性心律失常病史患者的不应期和传导时间进行比较。不应期和阈值由强度-间期曲线得出。测量所有诱发早搏的传导时间。在心动周期晚期诱发的早搏的阈值、不应期和传导时间并不能区分心房正常的患者与心动过缓或心动过速的患者。相比之下，心动周期早期早搏传导时间的增加将有这些异常的患者与心房正常的患者区分开来。心动周期早期早搏的房间和房内传导时间增加是原发性房性快速性心律失常（分别为r = 0.52，p = 0.0065和r = 0.274，p = 0.041）以及诱发重复性心房激动（分别为r = 0.65，p = 0.002和r = 0.59，p = 0.0001）的最强相关因素。心动周期早期早搏传导时间的这种增加可能使这些患者易患原发性房性快速性心律失常。
